Steroid sulphatase inhibitors

Details Steroid sulphatase inhibitors Steroid sulphatase inhibitors

1995-05-31

1999-01-19

Cook, Rebecca

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514182, 552506, A61K 3156, C07J 5300

Patent

active

058613900

ABSTRACT:
Steroid sulphatase inhibitors and pharmaceutical compositions containing them for use in the treatment of oestrone dependent tumors, especially breast cancer. The steroid sulphatase inhibitors are phosphonate esters of formula (I) ##STR1## where R is alkyl, alkenyl, cycloalkyl or aryl; and --O--polycycle represents the residue of a polycyclic alcohol such as a sterol, preferably a 3-sterol.

REFERENCES:
patent: 4937237 (1990-06-01), Holt et al.
patent: 5177064 (1993-01-01), Bodor et al.
Riess et al, Bulletin de la Societe Chemique de France pp. 933-941 1965.
CA101:171353, Gibbs et al, 1984.
RN 1100-39-5, 1967.
RN 2358-82-9, 1967.
RN 4281-98-5, 1967.

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