Steroid sulphatase inhibitors

Details Steroid sulphatase inhibitors Steroid sulphatase inhibitors

1991-10-18

1994-01-25

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514170, C07J 5100, A61K 3156

Patent

active

052815870

ABSTRACT:
The present invention provides pharmaceutical preparations for the treatment of estrogen dependent tumors. The pharmaceutical preparations contain an effective amount of a steroid sulphatase inhibitor of the formula: ##STR1## where R is alkyl, preferably C.sub.1 -C.sub.6 alkyl, and the ring system A B C D is a steroid nucleus selected from the group consisting of oestrone, dehydroepiandrosterone, substituted oestrones and substituted dehydroepiandrosterones or pharmaceutically acceptable salts thereof.

REFERENCES:
patent: 2878157 (1959-03-01), Bloom et al.
patent: 4150126 (1979-04-01), Fex et al.
International Search Report of related application CB 91/00270.
Steroids vol. 33, No. 5, May 1979, R. I. Cox et al., p. 549.

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