Steroid sulphatase inhibitors

Details Steroid sulphatase inhibitors Steroid sulphatase inhibitors

1995-06-02

1998-11-03

Cook, Rebecca

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

514456, 514457, 514459, 514460, 514517, A61K 31165

Patent

active

058308865

ABSTRACT:
Steroid sulphatase inhibitors and pharmaceutical compositions containing them for use in the treatment of oestrone dependent tumors, especially breast cancer. The steroid sulphatase are sulphamate esters of formula (I): ##STR1## where R.sub.1 and R.sub.2 are each H, alkyl, alkenyl, cycloalkyl or aryl, or together represent an alkylene group optionally containing a heteroatom e.g. --O-- or --NH--; and --O- polycycle represents the residue of a polycyclic alcohol such as a sterol, preferably a 3-sterol.

REFERENCES:
Townsley et al, Research Steriods, 5, 73-78, 1973.
Schwarz et al, Pharmagie 30, 17-21, 1975.
Zeitschrift fur Chemie, Schwarz et al 14(1) 1974 pp. 15-16.

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