Radiolabeled antibody cytotoxic therapy of cancer

Details Radiolabeled antibody cytotoxic therapy of cancer Radiolabeled antibody cytotoxic therapy of cancer

1990-12-05

1992-06-09

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 8591, 424 852, A61K 4300, A61K 39395

Patent

active

051205254

ABSTRACT:
Anticancer, antimicrobial and autoimmune disease, and anti-organ rejection therapy using cytotoxic agents is improved using cytokines to prevent, mitigate or reverse adverse radiation-induced or drug-induced toxicity, especially to hemotopoietic cells. Cytotoxic agents can include radioisotopes, drugs, toxins and even unconjugated cytotoxic antibodies. A preferred cytokine is IL-1. Higher doses of cytotoxic agents can be administered and tolerated by the patient and dose-limiting marrow toxicity can be prevented, palliated or reversed using adjunct cytokine therapy.

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