Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-11-14
2006-11-14
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S235200, C514S253070, C514S312000, C540S597000, C544S128000, C544S363000, C546S153000
Reexamination Certificate
active
07135466
ABSTRACT:
There are provided compounds which can be used in the treatment of diseases mediated by the autophosphorylation of a PDGF receptor, specifically, compounds which can inhibit neointima formation hypertrophy. The compounds are those represented by formula (I) or pharmacologically acceptable salts or solvates thereof:wherein R1and R2represent hydrogen, alkyl or the like; R3, R4, R5and R6represent hydrogen, halogen, alkyl, alkoxy or the like; R11and R12represent hydrogen, alkyl, alkylcarbonyl or the like; and A represents any one of formulae (i) to (x), provided that compounds wherein R3, R4, R5and R6represent hydrogen and A represents group (v) wherein u is 0 (zero) and R19represents phenyl optionally substituted by halogen, alkyl, or alkoxy are excluded.
REFERENCES:
patent: 4675047 (1987-06-01), Serban et al.
patent: 5480883 (1996-01-01), Spada et al.
patent: 6143764 (2000-11-01), Kubo et al.
patent: 3101544 (1982-08-01), None
patent: 860433 (1998-08-01), None
patent: 11-158149 (1999-06-01), None
patent: 00/43366 (2000-07-01), None
patent: WO 01/21594 (2001-03-01), None
CAPLUS Abstract 97:198123, 1982.
CAPLUS Abstract 133:135235, 2000.
CAPLUS Abstract 131:68130, 1999.
Simone, Oncology: Introduction, Cecil Textbook of Medicine, 20thEdition, vol. 1, pp. 1004-1010, 1996.
Traxler, Protein Tyrosine Kinase Inhibitors in Cancer Treatment, Exp. Opin. Ther. Patents 7(6):571-588, 1997.
Yarnal, et al., Database Crossfire Beilstein Online! Beilstein Institut zur Foerderung der Chemischen Wissenschaften, pp. 1-2, Database accession No. 561265, XP-002237136, “Cinnoline Chemistry. IV. Synthesis of Substituted Phenyl Cinnolyl Esters”, 1973.
Kazuo Kubo et al.: “A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation” Bioorg. Med. Chem. Lett., vol. 7, No. 23, pp. 2935-2940 1997.
George C. Wright et al.: “Synthesis and hypotensive properties of new 4-aminoquinolines” J. Med. Chem., vol. 14, No. 11, pp. 1060-1066 1971.
Hattab Alsaidi et al.: “Convenient synthesis of heteroaryl phenyl ethers from chloropyridines and chloroquinolines using phase-transfer catalysis” Synthesis, No. 11, pp. 921-924 1980.
Chemical Abstracts, vol. 58, 4563e, 1960.
Elaine F. Remmers, et al., “Cytokines and Growth Regulation of Synoviocytes from Patients with Rheumatoid Arthritis and Rats with Streptococcal Cell Wall Arthritis”, The Journal of Rheumatology, vol. 2, 1990, pp. 179-189.
Madathia Sarkissian, et al., “Transforming Growth Factor-βand Platelet Derived Growth Factor Regulation of Fibrillar Fibronectin Matrix Formation by Synovial Fibroblasts”, The Journal of Rheumatology, vol. 25, No. 4, 1998, pp. 613-622.
Annette B. Rice, et al., “Specific Inhibitors of Platelet-Derived Growth Factor or Epidermal Growth Factor Receptor Tyrosine Kinase Reduce Pulmonary Fibrosis in Rats”, American Journal of Pathology, vol. 155, No. 1, Jul. 1999, pp. 213-221.
Theresa C. Peterson, “Pentoxifyline Prevents Fibrosis in an Animal Model and Inhibits Platelet-derived Growth Factor-driven Proliferation of Fibroblasts”, Hepatology, vol. 17, No. 3, 1993, pp. 486-493.
Flemming S. Vassbotn, et al., “Activated Platelet-Derived Growth Factor Autocrine Pathway Drives the Transformed Phenotype of a Human Glioblastoma Cell Line”, Journal of Cellular Physiology, vol. 158, No. 2, 1994, pp. 381-389.
Furuta Takayuki
Miwa Atushi
Sakai Teruyuki
Senga Terufumi
Kirin Beer Kabushiki Kaisha
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
Rao Deepak
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