Quinobenzoxazine, antineoplastic agents

Details Quinobenzoxazine, antineoplastic agents Quinobenzoxazine, antineoplastic agents

1992-02-27

1994-06-07

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544 99, C07D49804, A61K 31535

Patent

active

053189655

ABSTRACT:
Quinobenzoxazine, derivatives of the formula ##STR1## as well as the pharmaceutically acceptable salts, esters, amides and prodrugs thereof are disclosed, wherein R.sup.1 is hydrogen or a carboxy-protecting group, R.sup.2 and R.sup.3 are substitutents, A is oxygen, Z is a halogen or a nitrogen-containing group, X is hydrogen, halogen or alkyl, and W is hydrogen, alkyl, amino or halogen. The compounds have potent antineoplastic activity.

REFERENCES:
patent: 4528285 (1985-01-01), Chu
patent: 4529725 (1985-07-01), Chu
patent: 4533663 (1985-08-01), Chu
patent: 4540694 (1985-09-01), Chu
patent: 4542133 (1985-09-01), Chu
patent: 4607032 (1986-08-01), Chu
patent: 4689325 (1987-08-01), Chu
patent: 4725595 (1988-02-01), Schriewer et al.
Harrison's Principles of Internal Medicine, Tenth Edition, pp. 453-456 (1983).

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