Quinazoline derivatives as medicaments

Details Quinazoline derivatives as medicaments Quinazoline derivatives as medicaments

2005-06-07

2005-06-07

Raymon, Richard L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S266210, C514S264110, C514S262100, C514S252170, C514S266200

Reexamination Certificate

active

06903096

ABSTRACT:
The invention is directed to methods to inhibit TGF-β and/or p38-α kinase using compounds of the formulaor the pharmaceutically acceptable salts thereofwherein R3is a noninterfering substituent;each Z is CR2or N, wherein no more than two Z positions in ring A are N, andwherein two adjacent Z positions in ring A cannot be N;each R2is independently a noninterfering substituent;L is a linker;n is 0 or 1; andAr′ is the residue of a cyclic aliphatic, cyclic heteroaliphatic, aromatic or heteroaromatic moiety optionally substituted with 1-3 noninterfering substituents.

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