Process for the preparation of C(5)-substituted 1,2-dihydro-5H-c

Details Process for the preparation of C(5)-substituted 1,2-dihydro-5H-c Process for the preparation of C(5)-substituted 1,2-dihydro-5H-c

1998-06-08

2000-07-25

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 13, C07D47100

Patent

active

060938269

ABSTRACT:
A method for preparing C(5)-substituted 1,2-dihydro-5H-chromeno[3,4-.function.]quinolines from a lactol precursor is provided. The method comprises converting the lactol to one of a select number of mixed acetal derivatives, and then treating the acetals with a Grignard reagent. The new process provides products in higher yield and greater purity. Novel intermediates of this method are also claimed.

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