Process for the preparation of an N-substituted 3-O-alkyl-14-hyd

Details Process for the preparation of an N-substituted 3-O-alkyl-14-hyd Process for the preparation of an N-substituted 3-O-alkyl-14-hyd

1981-08-17

1984-09-18

Williams, Howard S.

Chemistry: electrical and wave energy

Processes and products

Processes of treating materials by wave energy

546 45, B01J 1912, C07D49100

Patent

active

044722532

ABSTRACT:
A 14-hydroxy group is introduced into a morphinan structure by singlet oxygen reaction with a novel dienol ester of an N-substituted-3-O-alkylnormorphinone. To carry out the singlet oxygen reaction, the enolate substrate may be contacted with molecular oxygen in the presence of light and a light sensitizing agent or in the presence of a chemical reagent for forming singlet oxygen from molecular oxygen.

REFERENCES:
patent: 2772270 (1956-11-01), Weiss
patent: 4001249 (1977-01-01), Noyori et al.
Bentley, The Chemistry of the Morphine Alkaloids, (1954), pp. 251, 252 & . 2

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