Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1980-02-11
1982-07-13
Berch, Mark L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548475, C07D20948
Patent
active
043393829
ABSTRACT:
In the manufacture of N-aryl or alkylthiocarbamoyl-2-amino-1H-isoindole-1,3-(2H)diones of the type represented by the structural formula ##STR1## by ring closure of a corresponding ortho-carbonyl substituted benzoylhydrazine thiocarboxamide, greatly improved yields are obtained by cyclization of a compound of the structural formula: ##STR2## by reaction under mildly basic conditions at ambient or room temperature in the presence of a non-reactive polar organic solvent and a hindered aliphatic amine.
REFERENCES:
patent: 4264502 (1981-04-01), Patel et al.
patent: 4289527 (1981-09-01), Hedrich
patent: 4292071 (1981-09-01), Kirkpatrick
Sykes, "A Guide Book to Mechanisms in Organic Chem." (1966), pp. 72-25, 77.
Gould, "Mechanism & Structure in Organic Chem." (1959), Chapter 8, pp. 251-254, 268-269.
Buehler & Pearson, "Survey of Organic Synthesis" (1970), pp. 897-899, 907.
Berch Mark L.
Gulf Oil Corporation
Keith Deane E.
Stine Forrest D.
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