Polymorphic markers of the LSR gene

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C424S009200

Reexamination Certificate

active

07125667

ABSTRACT:
The invention provides novel LSR genomic sequences, polypeptides, antibodies, and polynucleotides including biallelic markers derived from the LSR locus. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype.

REFERENCES:
patent: 2767136 (1999-02-01), None
patent: WO 96/30400 (1996-10-01), None
patent: WO 96/34981 (1996-11-01), None
patent: WO 96/39429 (1996-12-01), None
patent: WO 97/27288 (1997-07-01), None
patent: WO 98/01257 (1998-01-01), None
patent: WO 98/20165 (1998-05-01), None
patent: WO 98/54311 (1998-12-01), None
patent: WO 99/07738 (1999-02-01), None
patent: WO 99/10492 (1999-03-01), None
patent: WO 99/21577 (1999-06-01), None
Bihain, B., et al.; “The lipolysis stimulated receptor: a gene at last”; Current Opinion in Lipodology, GB, London, vol. 9, No. 3, Jun. 1, 1998, pp. 221-224; ISSN: 0957-9672 1998 Lippincott-Raven Publishers [XP-002096548].
Bihain, B., et al.; “Lipolysis—stimulated receptro: A new-cotner on the lipoprotein research scene”; Diabete & Metabolisme, (1995) vol. 21, No. 2, pp. 121-126 [XP-000925423].
Ducohu, J.; “Lipoprotein receptors. Old acquaintances and newcomers !; Les recepteurs des liposproteines. Vieilles con-nainssanccs ct nouvcaurs venus”, Revue Medicale de Burx-elles (Feb. 1997) 18 (1) 10-5 [XP-000925412].
Zhao, L. P., et al.; “Mapping of complex traits by single-nucleotide polymrphisms”, American Journal of Human Gneetics, U.S., University of Chicago Press, Chicago, vol. 63, No. 1, 1998, pp. 225-240 [XP-000920771] ISSN: 0002-9297.
Alexeev and Yoon, “Stable and inheritable changes in genotype and phenotype of albino melanocytes induced by an RNA-DNA oligonucleotide,”Nature Biotech.,16:1343-1346, 1998.
Arita, et al., “Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity,” Biochem. and Biophys. Research Comm. 257:79-83, 1999.
Austin, et al., “Hypertriglyceridemia as a Cardiovascular Risk Factor,”Am. J. Cardiol.,81:7B-12b, 1998.
Baldo, et al., “The Adipsin-Acytation Stimulating Protein Sytem and Regulation of Intracellular Triglyceride Synthesis,” J. Clin. Invest., 92:1543-1547 (1993).
Bartles, J.R., et al., “Biogenesis of the Rate Hepatocyte Plasma Membrane,”Methods Enzymol.,191: 825-841, 1990.
Bihain, B.E., et al., “Characterization and purification of the Lipolysis-stimulated receptor,”Elsevier Science B.V.,pp. 465-470, 1995.
Bihain, B.E., e tal., “Free Fatty Acids Activate a High-Affinity Saturable Pathway for Degradation of Low-Density Lipoproteins in Fibroblasts from a Subject Homozygous for Famillal Hypercholesterolemia”Biochemistry,31:4628-4838, 1992.
Brendal, V., et al., “Methods and algorithms for statistical analysis of protein sequences,”Proc. Natl. Acad. Sci. USA,89:2002-2006, 1992.
Chan, .W.J., et al., “NPXY, a Sequence Often Found in Cytoplasmic Tails, Is Required for Coated Pit-mediated Internalization of the Low Density Lipoprotein Receptor”,J. Biol. Chem.,265:3116-3123, 1990.
Cole-Strauss et al., “Corrrection of the Mutation Responsible for Sickle Cell Anemia by an RNA-DNA Oligonucleotide,”Science,273:1386-1389, 1996.
Costet, P., et al., “Percodsome Proliferator-activated Receptor α-Isoform Deficiency Leads to Progressive Dyslipidemla with Sexually Dimorphic Obesity and Steatosis*”,J. Biol. Chem.,273, 29577-29585, 1998.
Davis, C.G., et al., “The J.D. Mutation in Familial Hypercholesterolemia: Amino Acid Substitution in Cytoplasmic Domain Impedes Internalization of LDL Receptors,”Cell,45:15-24, 1988.
Dietrich, J., et al., “CD3γ Contains a Phosphoserine-Dependent Di-Leucine Motif Involved in Down-Regulation of the T Cell Receptor”, EMBO Journal 13:2156-2166 1994.
Everhart, J.E., “Weight Change and Obesity After Liver Transplantation: Incidence and Risk Factors,”Liver Transpl. Surg.,4:285-296, 1998.
Feeman, Jr., W.E., “Hypertriglyceridemia dn Atherosclerosis,”Annals of Internal Medicine,vol. 128, No. 1, pp. 73-74, 1998.
Ghebrehiwet, et al., “Isolation, cDNA Cloning, and Overexpression of a 33-kD Cell Surface Glycoprotein that Binds to the Globualr “Heads” of C1q,”J. Exp. Med.,179:1809-1821 (1994).
Goldstein, J.L., et al., “Familial Hypercholesterolemia,”The Metabolic and Molecular Bases of Inherited Disease,vol. II, 7thEdition (Scriver, C.R., et al., ed). McGraw-Hill, New York, pp. 1981-2030, 1995.
Goldstein, et al., “Hyperlipidemia in Coronary Heart Disease,”J. Clin, Invest.,62:1533-1543, 1973.
Gura, et al., “Obesity Sheds its Secrets”,Science,275:751-753, Feb. 7, 1997.
Hayward, et al., “The cDNA Sequence of Human Endothelial Cell Multimerin,”J. Biol. Chem.,270:18246-18251, 1995.
Henrion, et al., “Structure, Sequence, and Chromosomal Location of the Gene for USF2 Transcription Factors in Mouse,” Genomics, 25:36-43 (1995).
Herz, J., et al., “Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor,” European Molecular Biology Laboratory, 7:4119-4127 (1988).
Honoré, B., et al., “Cloning and expression of a cDNA covering the complete coding region of the P32 subunit of human pre-mRNA splicing factor SF2,”Gene,134:283-287 (1993).
Hu, et al., “AdipoQ is a Novel Adipose-specific Gene Dysregulated in Obesity,”J. Biol. Chem.,271:10697-10703 (1996).
Huettinger , M., et al., “Characteristics of Chylomicron Remnant Uptake into Rat Liver,”Clin. Biochem.,21:87-92 (1988).
Huto, et al., “AdipoQ is a Novel Adipose-specific Gene Dysregulated in Obesity,”Jr. of Biol. Chem.,271, 18:10697-10703 (1996).
Imagawa, et al., “Structure-Function Studies of Human Leptin,”J. Biol. Chem.,273:35245-35249, 1998.
Karpe, F., et al., “Clearance of lipoprotein remnant particals in adipose tissue and muscle in humans,”J. Lipid Res.38:2335-2343 (1997).
Karpe, F., et al., “Magnitude of alimentary lipemia is related to intima-media thickness of the common carotid artery in middle-aged men,”Elsevier Science Ireland,141:307-314, 1998.
Kersten, S., et al., “Percodsome proliferator-activated receptor α mediates the adaptive response to fasting,”J. Clin. Invest,103:1489-1498, Jun. 1999.
Khallou, et al., “Correction of Delayed Postprandial Plasma Lipid Response in Genetically Obese Mice by Injection of Recombinant Leptin,” Abstract from the 69thScientific Sessions, New Orleans, LA; Supplemental to Circulation, American Heart Assoc., vol. 94:8 (1996).
Krainer, A.R., et al., “Functional Expression of Cloned Human Splicing Factor SF2: Homology to RNA-Binding Proteins, U1 7 0K, and Drosophila Splicing Regulators,”Cell,66:383-394, 1991.
Lee, M.G-S., et al., “Characterization of a cDNA Encoding a Cysteine-Rich Cell Surface Protein Located in the Flageliar Pocket of the ProtozoanTrypanosome brucel,” Molec. Cell. Biol.,10:4506-4517 (1990).
Letourneur, F., et al., “A Novel Di-Leucine Motif and a Tyrosine-Based Motif Independently Mediate Lyaosomal Targeting and Endocytosis of CD3 Chains,”Cell, 69:1143-1157 (1992).
Lewis, G.F., et al., “Postprandial Lipoprotein Metabolism in Normal and Obese Subjects: Comparison after the Vitamin A Fat-Loading Test,”Jr. of Clinic. Endo.,71:1041-1050, (1990).
Lin, et al., “Archaic Structure of the Gene Encoding Transcription Factor USF*”,Jr.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polymorphic markers of the LSR gene does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polymorphic markers of the LSR gene, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polymorphic markers of the LSR gene will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3644552

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.