Phenyl alcohol amides having anticonvulsant activity

Details Phenyl alcohol amides having anticonvulsant activity Phenyl alcohol amides having anticonvulsant activity

1993-06-03

1995-10-31

Kumar, Shailendra

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564161, C07C23305

Patent

active

054631254

ABSTRACT:
New anticonvulsant compounds include (.+-.)-2-hydroxy-2-phenylbutyramide and (.+-.)-3-hydroxy-3-phenylpentamide. These homologues of (.+-.)-4-hydroxy-4-phenylhexanamide have anticonvulsant activity as well as unexpected properties, particularly low neurotoxicity and pharmacological differences. The invention further provides methods for the synthesis of (.+-.)-2-hydroxy-2-phenylbutyramide and (.+-.)-3-hydroxy-3-phenylpentamide as exemplified in the examples.

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Nathan et al, Rev. Latinoamer, Quim, 9, 90 (1978).
Gallegos et al, J. of Pharmaceutical Sci, 79,(11), 1032-33, 1990.

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