Organic nitrate drug mixtures resistant to detonation by fire

Details Organic nitrate drug mixtures resistant to detonation by fire Organic nitrate drug mixtures resistant to detonation by fire

1984-04-17

1988-05-24

Robinson, Allen J.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

514509, A61K 3121, A61N 3348

Patent

active

047465069

ABSTRACT:
Detonatable organic nitrates which are blended with excipients in drug mixtures for use as vasodialators such as nitroglycerine/lactose are rendered nondetonatable when burned in smoldering fires by the incorporation therewith of minor amounts of alkaline solid material such as magnesium carbonate and hydroxide.

REFERENCES:
patent: 307988 (1884-11-01), Robertson
patent: 525188 (1894-08-01), Callahan et al.
patent: 1905289 (1929-08-01), Holmes
patent: 2140447 (1938-12-01), Ayers
patent: 2140897 (1938-12-01), Challenor et al.
patent: 2351468 (1944-06-01), Woodbury
Lachman et al., The Theory and Practice of Industrial Pharmacy 2nd Ed., Lea & Febiger 1976 pp. 333, 341.
Foye "Principles of Medicinal Chemistry" Lea & Febiger pp. 390-394.

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