Novel prostanoic acid derivatives and process for the preparatio

Details Novel prostanoic acid derivatives and process for the preparatio Novel prostanoic acid derivatives and process for the preparatio

1974-12-19

1977-01-18

Demers, Arthur P.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

260240R, 2603403, 2603405, 2603407, 2603409, 260514D, 260468R, 260468D, 260611R, 424282, 424305, 424317, 424318, 424312, 424339, A01N 928, A61K 31335

Patent

active

040040208

ABSTRACT:
Prostaglandins of the formula ##STR1## wherein R.sub.1 is hydroxymethyl, carboxy, aryloxycarbonyl, alkoxycarbonyl of 1-8 carbon atoms in the alkoxy group, or the group -COO-CH.sub.2 -U-V wherein U is a direct C-C bond, carbonyl or carbonyloxy and V is phenyl substituted by phenyl, alkoxy of 1-2 carbon atoms or halogen; R.sub.2 is hydroxy and R.sub.3 is a hydrogen atom or R.sub.2 and R.sub.3 collectively are an oxygen atom; A is -CH.sub.2 -CH.sub.2 or trans-CH=CH; B is -CH.sub.2 -CH.sub.2 or CH=CH; one of R.sub.4 and R.sub.5 is hydroxy and the other is a hydrogen atom; R.sub.6 and R.sub.7 each are alkyl of 1-10 carbon atoms or collectively are alkylene of up to 7 carbon atoms and with 2-3 carbon atoms in the chain, phenylene or naphthylene; R.sub.8 is a hydrogen atom or alkyl of 1-5 carbon atoms; ##STR2## when R.sub.2 is hydroxy and R.sub.3 is a hydrogen atom or is ##STR3## or -CH=CH- when R.sub.2 and R.sub.3 collectively are an oxygen atom; or, when R.sub.1 is carboxy, a physiologically acceptable salt thereof with a base, possess the activity of the corresponding natural prostaglandins, including a luteolytic effect, and are useful in triggering abortions and syncronizing the conception cycle of mammals.

REFERENCES:
patent: 3833612 (1974-09-01), Wendler et al.
patent: 3845042 (1974-10-01), Strike et al.
patent: 3850952 (1974-11-01), Kuo et al.
patent: 3864387 (1975-02-01), Nelson
patent: 3873570 (1975-03-01), Kelly

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