Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-06-17
1989-06-20
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514183, 5142222, 5142288, 514277, 514359, 514408, 514430, 514438, 514449, 514463, 514466, 514468, 514533, 514534, 514544, 514510, 514824, 544 2, 544 3, 544 59, 544 63, 544106, 546206, 546400, 549 13, 549 14, 549 29, 549 30, 549356, 549359, 549429, 560 51, 560 53, 560 56, C07C26530, A61K 31235, A61K 31535
Patent
active
048409510
ABSTRACT:
Naphthalene derivative of the formula: ##STR1## wherein Ring A is a substituted or unsubstituted benzene ring; each of R.sup.1 and R.sup.2 is a group of the formula: --OR.sup.5, --NHR.sup.5 or ##STR2## or either one of R.sup.1 and R.sup.2 is a lower alkoxy group and the other one is a group of the formula: --OR.sup.5, --NHR.sup.5 or ##STR3## each of R.sup.3 and R.sup.4 is a lower alkoxy group, or one of R.sup.3 and R.sup.4 is a lower alkoxy group and the other is a hydrogen atom; R.sup.5 is a substituted alkyl group, a heterocyclic group, a cycloalkyl group, an alkyl group of at least 5 carbon atoms or alkenyl group; and each of R.sup.6 and R.sup.7 is hydrogen atom or a lower alkyl group and salts thereof are disclosed. Said naphthalene derivative (I) and its salts have excellent hypolipidemic activity and are useful for treatment or prophylaxis of hyperlipidemia and/or arteriosclerosis.
REFERENCES:
G. Traverso, "Intermedi necessari nella syntesi di taluni resinoli & loroderivati", Gazzetta Chimica Italiana, vol. 88, Fasc. VI-VII (1958).
Giorgio Traverso, "Intermediates for the Synthesis of Resinols and Derivatives", Chem. Abstr., vol. 55, 20025i-20027i (1958).
Gonzalez et al., "Synthesis of Two Arylnaphthalene Lignans", Tetrahedon, vol. 34, 1011-1013 (1978).
Ghosal et al., "Two New Aryl Naphthalide Lignans from Polygala Chinensis", Phytochemistry, vol . 13, 1933-1936 (1974).
Plaumann et al., "Potential Isobenzofurans: Their Use in the Synthesis of Naturally Occurring 1-Arylnaphthalide Lignans", J.C.S. Chem. Comm., 354-355 (1980).
de Silva et al., "A Regiocontrolled Synthesis of Some Arylnaphthalide Lignans", J.C.S. Chem. Comm., 995-997, (1980).
Keay et al., "Hydroxyacetals, Phthalans, and Isobenzofurans Therefrom", Can. J. Chem., vol. 61, 1987-1995 (1983).
Iwasaki Tameo
Takashima Kohki
Covington Raymond
Raymond Richard L.
Tanabe Seiyaku Co. Ltd.
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