Novel immunological adjuvants, process for their production and

Details Novel immunological adjuvants, process for their production and Novel immunological adjuvants, process for their production and

1976-08-03

1978-08-29

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

2601125R, 424177, A61K 3902, C07C10352, A61K 3700

Patent

active

041104340

ABSTRACT:
Novel derivatives with immunological activity are obtained by reacting a hydrosoluble extract of mycobacteria with an aliphatic acid derivative containing 10 to 18 carbon atoms and isolating the resulting product. The hydrosoluble extract of mycobacteria is a tetrasaccharide-heptapeptide or its dimer, trimer or tetramer possibly associated with non-amino reducing sugars. The derivative has the formula: ##STR1## IN WHICH M IS A WHOLE NUMBER COMPRISED BETWEEN 1 AND 4 INCLUSIVE, N IS A WHOLE NUMBER AT LEAST EQUAL TO 1 AND R is an alkyl radical containing 9 to 17 carbon atoms.

REFERENCES:
patent: 3429868 (1969-02-01), Kominati
patent: 3941762 (1976-03-01), Parker
patent: 3956481 (1976-05-01), Jolles et al.
patent: 3992528 (1976-11-01), Graham et al.
patent: 4013788 (1977-03-01), Jolles et al.
Biochem. & Biophys. Res. Comm. 26, (1967), pp. 492-496.

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