Novel compounds of the muramyl peptide

Details Novel compounds of the muramyl peptide Novel compounds of the muramyl peptide

1985-11-07

1987-09-15

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 552, A61K 3170, C07H 504

Patent

active

046939989

ABSTRACT:
The compounds have the structure 2-(2-amino or alkyl-amido-2-desoxy-3-O-D-glucopyranosyl)-alkanyl-dipeptide, possibly substituted on the saccharide residue the amino acid residue at the end of the peptide chain being a D-glutamyl residue whose .alpha.-carboxy function is esterified and .gamma.-carboxyl function amidated. The compounds are valuable as immunological medicaments.

REFERENCES:
patent: 4153684 (1979-05-01), Audibert et al.
Kusumoto et al., Chemical Abstract, 89, 215758(b), (1978).
Adams et al., Bichem. Biophy. Comm. 72(1), 339-346 (1976).
Kotani et al., Biken Journal, 18, 105-111, (1975).
Chedid et al., Proc. Natl. Acad. Sci., 75, 2472-75 (1976).

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