Nontoxic potentiation/sensitization of cancer therapy by...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S681000, C514S684000

Reexamination Certificate

active

07091241

ABSTRACT:
A combination of Vitamin C and a quinone used as a supplemental treatment for a cancer patient. The combination may be administered before, during and after the patient undergoes a conventional cancer treatment protocol. The combination may be administered orally, intravenously, or intraperitoneally. Oral administration may be in the form of capsules containing a predetermined ratio of Vitamin C to Vitamin K3. The supplemental treatment is effective to inhibit metastases of cancer cells and inhibit tumor growth. The ratio of Vitamin C to Vitamin K3is in the range of about 50 to 1 to about 250 to 1. A method for evaluating the effectiveness of the supplemental treatment includes monitoring the patient's serum DNase activity throughout the course of treatment.

REFERENCES:
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Noto, Vencenzo; Taper, Henryk S.; Yi-Hua, Jiang; Janssens, Jaak; Bonte, Jan; De Loecker, William;Effects of Sodium Ascorbate(Vitamin C)and 2-Methyl-1,4- Napthoquinone(Vitamin K3)Treatment of Human Tumor Growth in Vitro, I. Synergism of Combined Vitamin C and K3Action; Cancer, Mar. 1, 1989, vol. 63.
Taper, H and Roberfroid, M.;Cancer Chemotherapy Potentiation Induced by Combined Vitamin C and Vitamin K3with Ferrous Sulfate Pretreatment; Oncology (Life Science Adv.) 1992 11:19-25.
Taper, Henryk S.; de Gerlache, Jacques; Lans, Marc, Roberfroid, Marcel;Non-Toxic Potentiation of Cancer Chemotherapy by Combined C and K3Vitamin Pretreatment; Int. J. Cancer; 1987, 40; 575-579.
Taper, H.S.; Roberfroid, M.;Non-Toxic Sensitization of Cancer Chemotherapy by Combined Vitamin C and K3Pretreatment in a Mouse Tumor Resistant to Oncovin; Anticancer Research 1992, 12: 1651-1654.
Taper, H. S.Reversibility of Acid and Alkaline Deoxyribonuclease Deficiency in Malignant Tumor Cells; The Journal of Histochemistry and Cytochemistry 1981; vol. 29, No. 9, pp. 1053-1060.
De Loecker, William, Janssen, Jaak, Bonte, Jan, and Taper, Henyrk S.;Effects of Sodium Ascorbate(Vitamin C)and 2-Methyl-1,4- Napthoquinone(Vitamin K3)Treatment of Human Tumor Growth in Vitro; II Synergism with Combined Chemotherapy Action; Anticancer Research 13: 1993; 103-106.
Taper, Henryk S.; Keyeus, Andre, Roberfroid, Marcel;Potentiation of Radiotherapy by Nontoxic Pretreatment of Combined Vitamin C and Vitamin K3in Mice Bearing Solid Transplantable Tumor; Anticancer Research 16, 1996, 499-504.

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