Non-peptidic angiotensin-II-receptor-antagonists

Details Non-peptidic angiotensin-II-receptor-antagonists Non-peptidic angiotensin-II-receptor-antagonists

1992-04-15

1995-01-03

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514 80, 514 81, 5142232, 544 10, 544 12, C07D28524, C07D41704/417/14, A61K 3154

Patent

active

053787048

ABSTRACT:
Novel compounds having the formula ##STR1## wherein R.sub.1, R.sub.2, X and Y are as defined herein. These compounds inhibit the action of angiotensin II and are useful, therefore, for example, as antihypertensive agents.

REFERENCES:
patent: 4870186 (1989-09-01), Aldrich
J. H. Freeman et al., "1,2,4-Benzothiadiazine Dioxides and 3,4-Dihydro-3,4-Dihydro-1,2,4-Benzothiadiazine Dioxides", J. Org. Chem 16, 815 (1951).
Chemical Abstract, 58, 4570f (1963).
K. S. Atwal et al., "Substituted 1,4-Dihydropyrimidines. 3. Synthesis of Selectively Functionalized 2-Hetero-1,4-dihydropyrimidines", J. Org. Chem 54, 25 (1989), pp. 5898-5907.

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