Nicotinamide derivatives useful as p38 inhibitors.

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S316000, C546S317000

Reexamination Certificate

active

07125898

ABSTRACT:
Compounds of formula (I):are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.

REFERENCES:
patent: 4200750 (1980-04-01), Warner et al.
patent: 4968804 (1990-11-01), Stanek et al.
patent: 5064832 (1991-11-01), Stanek et al.
patent: 5236934 (1993-08-01), VanAtten
patent: 5246943 (1993-09-01), Blankley et al.
patent: 5521213 (1996-05-01), Prasit et al.
patent: 5534518 (1996-07-01), Henrie et al.
patent: 5658903 (1997-08-01), Adams et al.
patent: 5858995 (1999-01-01), Kawai et al.
patent: 5877190 (1999-03-01), Dhainaut et al.
patent: 5932576 (1999-08-01), Anantanarayan et al.
patent: 5945418 (1999-08-01), Bemis et al.
patent: 5977103 (1999-11-01), Adams et al.
patent: 6060491 (2000-05-01), Pruitt et al.
patent: 6080767 (2000-06-01), Klein et al.
patent: 6087496 (2000-07-01), Anantanarayan et al.
patent: 6130235 (2000-10-01), Mavunkel et al.
patent: 6147080 (2000-11-01), Bemis et al.
patent: 6174887 (2001-01-01), Haruta et al.
patent: 6251914 (2001-06-01), Adams et al.
patent: 6277989 (2001-08-01), Chakravarty et al.
patent: 6323227 (2001-11-01), Klein et al.
patent: 6392047 (2002-05-01), Geissler et al.
patent: 6399627 (2002-06-01), Song et al.
patent: 6420561 (2002-07-01), Haruta et al.
patent: 6436925 (2002-08-01), Lubisch et al.
patent: 6448257 (2002-09-01), Mavunkel et al.
patent: 6451794 (2002-09-01), Beswick et al.
patent: 6498166 (2002-12-01), Campbell et al.
patent: 6509361 (2003-01-01), Weier et al.
patent: 6509363 (2003-01-01), Salituro et al.
patent: 6545054 (2003-04-01), Song et al.
patent: 6576632 (2003-06-01), Goldstein et al.
patent: 6579872 (2003-06-01), Brown et al.
patent: 6605625 (2003-08-01), Peukert et al.
patent: 6638980 (2003-10-01), Su et al.
patent: 6696464 (2004-02-01), McClure et al.
patent: 6774127 (2004-08-01), Adams et al.
patent: 6699994 (2004-09-01), Babu et al.
patent: 6794377 (2004-09-01), Peukert et al.
patent: 6821965 (2004-11-01), Brown et al.
patent: 6855719 (2005-02-01), Thomas et al.
patent: 6867209 (2005-03-01), Mavunkel et al.
patent: 6924392 (2005-08-01), Peukert et al.
patent: 6936719 (2005-08-01), Babu et al.
patent: 6956037 (2005-10-01), Brown et al.
patent: 2001/0011135 (2001-08-01), Reidl et al.
patent: 2003/0055088 (2003-03-01), Shao et al.
patent: 2003/0139605 (2003-07-01), Riedl et al.
patent: 2003/0225089 (2003-12-01), Jung et al.
patent: 2004/0038858 (2004-02-01), Dorsch et al.
patent: 2004/0053942 (2004-03-01), Alberti et al.
patent: 2004/0116479 (2004-06-01), Haviv et al.
patent: 2004/0138287 (2004-07-01), Barth et al.
patent: 2004/0162281 (2004-08-01), Babu et al.
patent: 2004/0176446 (2004-09-01), Alonso-Alija et al.
patent: 2004/0242868 (2004-12-01), Angell et al.
patent: 2004/0249161 (2004-12-01), Angell et al.
patent: 2004/0254200 (2004-12-01), Davis et al.
patent: 2004/0266839 (2004-12-01), Angell et al.
patent: 2004/0267012 (2004-12-01), Angell et al.
patent: 2005/0020540 (2005-01-01), Angell et al.
patent: 2005/0020590 (2005-01-01), Lang et al.
patent: 2005/0038014 (2005-02-01), Angell et al.
patent: 2005/0065195 (2005-03-01), Angell et al.
patent: 2005/0090491 (2005-04-01), Angell et al.
patent: 2005/0176964 (2005-08-01), Aston et al.
patent: 0 533 266 (1992-09-01), None
patent: 0 533 268 (1992-09-01), None
patent: 0 346 841 (2003-06-01), None
patent: 0 430 033 (2004-04-01), None
patent: 2 276 161 (1993-03-01), None
patent: 2 276 162 (1993-03-01), None
patent: 2 273 930 (1993-12-01), None
patent: 2 295 387 (1996-05-01), None
patent: 11218884 (1999-08-01), None
patent: WO 94/15920 (1994-07-01), None
patent: WO 95/06636 (1995-03-01), None
patent: WO 95/06644 (1995-03-01), None
patent: WO 95/11243 (1995-04-01), None
patent: WO 95/15954 (1995-06-01), None
patent: WO 95/17401 (1995-06-01), None
patent: WO 95/29907 (1995-11-01), None
patent: WO 95/30675 (1995-11-01), None
patent: WO 96/31508 (1996-10-01), None
patent: WO 96/31509 (1996-10-01), None
patent: WO 97/03034 (1997-01-01), None
patent: WO 98/57934 (1998-12-01), None
patent: WO 99/32463 (1999-07-01), None
patent: WO 00/12074 (2000-03-01), None
patent: WO 00/12497 (2000-03-01), None
patent: WO 00/26216 (2000-05-01), None
patent: WO 00/56738 (2000-09-01), None
patent: WO 00/71493 (2000-11-01), None
patent: WO 00/71509 (2000-11-01), None
patent: WO 00/71510 (2000-11-01), None
patent: WO 00/71511 (2000-11-01), None
patent: WO 01/27089 (2001-04-01), None
patent: WO 01/34605 (2001-05-01), None
patent: 01/70695 (2001-09-01), None
patent: WO 01/87875 (2001-11-01), None
patent: WO 02/40486 (2002-05-01), None
patent: WO 03/032970 (2003-04-01), None
patent: WO 03/093248 (2003-11-01), None
patent: WO 04/010995 (2004-02-01), None
patent: WO 04/089874 (2004-10-01), None
patent: WO 04/089875 (2004-10-01), None
patent: WO 04/089876 (2004-10-01), None
patent: WO 05/014550 (2005-02-01), None
patent: WO 05/073189 (2005-08-01), None
patent: WO 05/073217 (2005-08-01), None
patent: WO 05/073219 (2005-08-01), None
patent: WO 05/073232 (2005-08-01), None
Boehm et al.,Expert Opinion of Therapeutic Patents, vol. 10 (1) pp. 25-37 (2000).
Boehm, et al,Journal of Medicinal Chemistry, vol. 39(20) pp. 3929-3937 (1996).
Ceccarelli et al.,European Journal of Medicinal Chemistry, vol. 33 (12) pp. 943-955 (1998).
Gabriele et al.,European Journal of Organic Chemistry, vol. 2001 (24) pp. 4607-4613 (2001).
Han et al.,Biohemica et Biophysica Acta—Molecular Cell Research, vol. 1265 (2-3) pp. 224-227 (1995.
Hanson,Expert Opinion on Therapeutic Patents, vol. 7(7) pp. 729-733 (1997).
Henry et al.,Drugs of the Future, vol. 24 (12) pp. 1345-1354 (1999).
Jiang et al,Journal of Biological Chemisrtry, vol. 271 (30) pp. 17920-17926 (1996).
Li et al.,Biochemical and Biophysicall Research Communications, vol. 228 (2) pp. 334-340 (1996).
Liebeskind et al.,Organic Letters, vol. 4 (6) pp. 979-981 (2002).
Moreland et al.,Annals of Internal Medicine, vol. 130 (6) pp. 478-486 (1999).
Murali Dhar et al.,Bioorganic and Medicinal Chemistry Letters, vol. 12 (21) pp. 3125-3128 (2002).
Rankin et al.,British Journal of Rheumatology, vol. 34 pp. 334-342 (1995).
Salituro et al.,Current Medicinal Chemistry, vol. 6 pp. 807-823 (1999).
Wang et al.,Journal of Biological Chemistry, vol. 272 (38) pp. 23668-23674 (1997).
Marin, et al., Blood, vol. 98(3) pp. 667-673 (2001).
Foster, et al., Drug News Perspect., vol. 13(8) pp. 488-497 (2000).
U.S. Appl. No. 10/513,095, filed Aug. 26, 2005, Angell et al.
U.S. Appl. No. 10/492,714, filed Apr. 15, 2004, Angell et al.
U.S. Appl. No. 10/568,121, filed Feb. 9, 2006, Walker.
U.S. Appl. No. 10/522,955, filed Nov. 11, 2005, Angell et al.
U.S. Appl. No. 10/551,503, filed Sep. 30, 2005, Aston.
U.S. Appl. No. 10/551,501, filed Sep. 30, 2005, Aston.
U.S. Appl. No. 10/551,502, filed Sep. 30, 2005, Aston et al.
Henry, J. et al., “Potent Inhibitors of the MAP Kinase p38”, Bioogranic & Medicinal Chemistry Letters 8 (1998) pp. 3335-3340.
Courtney, S. et al., “2,3-Dihydro-1,3-dioxo-1H-isoindole-5-carboxylic aicd derivatives: a novel class of small molecule heparanase inhibitors”, Bioorganic & Medicinal Chemistry Letters 14 (2004), pp. 3269-3273.
Boehm, J. et al., “New Inhibitors of p38 kinase”, Expert Opinion on Therapeutic Patents, 10(1), Ashley Publications, (2000), pp. 25-37.

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