Natural intense sweeteners

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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Details

424439, 426534, 426548, 426658, 426660, 514175, 536 6, 540115, A61K 3500, A61K 31705

Patent

active

051984270

ABSTRACT:
The present invention relates to novel sweet compounds derived from the leaves of the subtropical weed Abrus precatorius, and their use as sweeteners. In particular, the present invention contemplates four novel sweet compounds isolated from A. precatorius or A. fruticulosus, and particularly, Abrusosides A, B, C and D and related compounds. The present invention also contemplates the use of these abrusosides and related compounds as sugar substitutes. The present invention contemplates the use of Abrusosides A-D as individual components or in mixtures, in a method for sweetening comestibles, foodstuffs, beverages and medicinal agents.

REFERENCES:
Pharm. J. Trans. Third Ser. 24: 937-938 (May 1894) David Hooper "Abrus Precatorius; A Chem. Examination of the Leaves and Roots".
Nigerian Journal of Pharmacy vol. 12, No. 2 (Mar.-Apr. 1981) B. A. Akinloye, et al. "Abrus Precatorius Leave-A Source of Glycyrrhizin".
J. Chem. Soc., Chem. Commun., pp. 1197-1198 (1982) Hson-Mou Chang, et al. "Isolation and Structure Elucidation of Abruslactone A: a New Oleanene-".
Kusama et al.; Agric. Biol. Chem. 50(10):2445-2451 (1986).
Nishizawa et al.; Tet. Lett. 29(36):4597-4598 (1988).
Markham et al.; Phytochemistry 28(1):299-301 (1988).
Takeshita et al.; Chem. Pharm. Bull. 37(3):846-848 (1989).
Choi et al.; J. Chem. Soc., Chem. Commun. 13:887-888 (Jul. 1, 1989).
Choi et al.; J. Nat. Prod. 52(5):1118-1127 (Sep./Oct. 1989).
Fullas et al.; Planta Med. 56(3):332-333 (Jun. 1990).
Sakai et al.; Chem. Pharm. Bull. 38(3):824-826 (Mar. 1990).
The Merck Index; 10th Ed. p. 647 (1985).
Goodman & Gilman's; The Pharmacological Basis of Therapeutics; 7th Ed. pp. 946-947; (1985).

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