N-(heterocycle)alkyl)-1H-pyrazole-1-alkanamides as antiarrhythmi

Details N-(heterocycle)alkyl)-1H-pyrazole-1-alkanamides as antiarrhythmi N-(heterocycle)alkyl)-1H-pyrazole-1-alkanamides as antiarrhythmi

1989-03-22

1990-02-06

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514252, 514256, 514326, 514341, 514397, 514404, 544333, 544371, 544405, 546211, 546279, 548336, 548364, 548374, A61K 31415, C07D40312

Patent

active

048988804

ABSTRACT:
N-[(heterocycle)alkyl]-3,4 (or 4,5)-diaryl-1H-pyrazole-1-acetamides and pyrazole-1-propanamides, useful for treating cardiac arrhythmias in mammals, are prepared by reacting a lower-alkyl ester of pyrazole-1-acetic or propanoic acid with an appropriate (heterocycle-alkyl) amine or by reacting a pyrazole-1-acetic or propanoic acid with an appropriate (heterocycle-alkyl)amine.

REFERENCES:
patent: 4182895 (1980-01-01), Bailey
Ezrin et al. FASEB Journal 2,A1557 (1988).

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