N-(aryl/heteroaryl) amino acid derivatives pharmaceutical compos

Details N-(aryl/heteroaryl) amino acid derivatives pharmaceutical compos N-(aryl/heteroaryl) amino acid derivatives pharmaceutical compos

1997-11-21

2000-08-01

Burn, Brian M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514399, 5483355, 560 41, A01N 3720, A01N 4350, C07C22924, C07D23361

Patent

active

06096782&

ABSTRACT:
Disclosed are compounds which inhibit .beta.-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits .beta.-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

REFERENCES:
patent: 5536737 (1996-07-01), Kobayashi et al.
patent: 5552415 (1996-09-01), May
Database CAPLUS on STN, No. 94:133017, Kourai, `Antimicrobial activities of amino acid derivatives 2. Antimicrobial activities of N-p-chlorophenylglycyl-D,L-alanine and N-p-chlorophenylglycyl-L-leucine.` abstract of Bokin Bobai (1980), 8(12), pp. 517-525.
Iwakura, et al., "Reaction of Alkylidenepseudoxazolones With Amines", Tetrahedron, vol. 24, pp. 575-583, 1968.
Papadopoulos, et al., Tetrahedron, 47(4/5):563-572 (1991).
Waldmann, et al., Tetrahedron Letters, 37(48):8725-8728 (1996).

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