N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as CCR33...

Details N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as CCR33... N-(4-aryloxypiperidin-1-ylalkyl) cinnamic amides as CCR33...

2006-04-25

2006-04-25

Chang, Celia (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S235500, C514S253120, C514S326000, C544S129000, C544S360000, C546S216000, C546S210000, C546S221000

Reexamination Certificate

active

07034042

ABSTRACT:
Compounds of formula (I) in free or salt form, where Ar1is phenyl substituted by one or more substituents selected from halogen, cyano, nitro, and C1–C8-alkyl optionally substituted by cyano or halogen, Ar2is phenyl optionally which is unsubstituted or substituted by one or more substituents selected from halogen, cyano, hydroxy, nitro, C1–C8-alkyl, C1–C8-haloalkyl, C1–C8-alkoxy or C1–C8-alkoxycarbonyl, R1is C1–C8-alkyl substituted by hydroxy, C1–C8-alkoxy, acyloxy, —N(R2)R3, halogen, carboxy, C1–C8-alkoxycarbonyl, phenyl-C1–C8-alkoxycarbonyl, —CON(R4)R5or by a monovalent cyclic organic group, R2and R?3are each independently hydrogen or C1–C8-alkyl, or R2is hydrogen and R3is acyl or SO2R6, or R2and R3together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, R4and R5are each independently hydrogen, C1–C8-alkyl optionally substituted by hydroxy or phenyl, or phenyl optionally substituted by C1–C8-alkyl, halogen, cyano or C1–C8-alkoxy, or R4and R5together with the nitrogen atom to which they are attached denote a 5- or 6-membered heterocyclic group, R?6is C1–C8-alkyl, C1–C8-haloalkyl, or phenyl optionally substituted by C1–C8-alkyl, and n is 1, 2, 3 or 4. The compounds are useful as pharmaceuticals.

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