Monoorganylation of dihaloaromatics

Details Monoorganylation of dihaloaromatics Monoorganylation of dihaloaromatics

1984-02-24

1985-08-27

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

570190, 568634, 568647, C07C 4118, C07C 1700, C07C 2502, C07C 2518

Patent

active

045380031

ABSTRACT:
Process for the monoalkylation/monoarylation of dihaloaromatic compounds by treating the latter with selected magnesium or zinc organometallic reagents in the presence of a nickel/bidentate or tridentate phosphorus ligand. The products are intermediates to agricultural and pharmaceutical compounds.

REFERENCES:
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Tamao et al., Bull. Chem. Soc. Japan 49 (1976), 1958-1969.
Minato et al., Tetrahedron Lett., 21 (1980) 845-848.
King et al., Inorg. Chem. 10 (1971), 1841-1850.
Corriu et al., JCS Chem. Comm., 144 (1972).
Tamao et al., J. Am. Chem. Soc., 94, pp. 4374 to 4376 (1972).
March, "Advanced Organic Chemistry", McGraw-Hill, NY, 1968, p. 509.
Coffey, Ed., "Rodd's Chemistry of Carbon Compounds", 2nd Edition, vol. IIIA, Elsevier, NY, 1971, pp. 241 to 287.
Negishi, Acc. Chem. Res., 15, 340 to 348 (1982) [Larson et al., Tetrahedron Lett., 5041 (1979)].
Eapen et al., J. Org. Chem., 1984, 49, 478 to 482.

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