Method to reduce particle size growth during lyophilization

Details Method to reduce particle size growth during lyophilization Method to reduce particle size growth during lyophilization

1992-12-09

1994-04-12

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424 9, 424489, 424499, 514171, 514777, 514788, 514951, A61K 951

Patent

active

053024010

ABSTRACT:
This invention discloses a composition comprised of nanoparticles having a surface modifier adsorbed on the surface thereof and a cryoprotectant associated therewith, which cryoprotectant is present in an amount sufficient to form a nanoparticle-cryoprotectant composition. A preferred surface modifier is polyvinylpyrrolidone, and a preferred cryoprotectant is a carbohydrate such as sucrose. This invention further discloses a method of making nanoparticles having a surface modifier adsorbed on the surface and a cryoprotectant associated therewith, comprised of contacting said nanoparticles with the cryoprotectant for a time and under conditions sufficient to form a nanoparticle-cryoprotectant composition.

REFERENCES:
patent: 5145684 (1992-09-01), Liversidge et al.

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