Chemistry: analytical and immunological testing – Metal or metal containing – Present in biological fluids
Patent
1992-07-27
1994-04-05
Housel, James C.
Chemistry: analytical and immunological testing
Metal or metal containing
Present in biological fluids
436169, 436 79, 436171, 436172, 436805, 436810, 436530, 436531, 422 56, 422 57, 422 8205, 427 2, 427 8, G01N 2178, G01N 3352
Patent
active
053004396
ABSTRACT:
A test device and method of determining the presence or concentration of a predetermined ion, such as a cation of medical interest, like sodium, potassium, calcium, magnesium or lithium, in an aqueous test sample are disclosed. The test device includes a test pad comprising a hydrophilic indicator reagent composition capable of interacting with a predetermined ion, or electrolyte, to produce a detectable or measurable response. The hydrophilic indicator reagent composition consists essentially of a hydrophobic ion specific ionophore, a hydrophobic reporter substance, and a stabilizer polymer such as gelatin. The hydrophilic indicator reagent composition, either as a film or layer, or after incorporation into a suitable carrier matrix, provides a test pad of sufficient sensitivity to the predetermined ion to achieve an accurate and trustworthy electrolyte assay of an aqueous test sample, such as plasma or serum, by a dry phase test strip assay.
REFERENCES:
patent: 4645744 (1987-02-01), Charlton et al.
patent: 4780411 (1988-10-01), Piejko et al.
Coe Roger N.
Housel James C.
Miles Inc.
Redding David
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