Inorganic ion receptor active compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...

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514655, 564374, 564378, 564381, 564384, 564387, 564389, 564392, A61K 31135, C07C21758

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active

059815990

ABSTRACT:
The present invention features compounds able to modulate one or more activities of an inorganic ion receptor and methods for treating diseases or disorders using such compounds. Preferred compounds can mimic or block the effect of extracellular calcium on a cell surface calcium receptor.

REFERENCES:
patent: 2276618 (1942-03-01), Kulz
patent: 2930731 (1960-03-01), Heinzelmann et al.
patent: 2949359 (1960-08-01), Blout et al.
patent: 3202711 (1965-08-01), Frushstorfer et al.
patent: 3262977 (1966-07-01), Harsanyi et al.
patent: 3493662 (1970-02-01), Duerr et al.
patent: 3536712 (1970-10-01), Keck et al.
patent: 3689524 (1972-09-01), Jack et al.
patent: 3842067 (1974-10-01), Sarantakis
patent: 3862925 (1975-01-01), Sarantakis
patent: 3972859 (1976-08-01), Fujino et al.
patent: 4000197 (1976-12-01), Barfknecht et al.
patent: 4014937 (1977-03-01), Richardson
patent: 4098890 (1978-07-01), Molloy
patent: 4105602 (1978-08-01), Colescott et al.
patent: 4242355 (1980-12-01), Nedelec et al.
patent: 4289787 (1981-09-01), Molloy et al.
patent: 4360511 (1982-11-01), Baldwin et al.
patent: 4391826 (1983-07-01), Mills et al.
patent: 4487965 (1984-12-01), Himmele et al.
patent: 4587253 (1986-05-01), Halczenko et al.
patent: 4591605 (1986-05-01), Ray et al.
patent: 4608391 (1986-08-01), Ginos et al.
patent: 4609494 (1986-09-01), Baldwin et al.
patent: 4647446 (1987-03-01), Sargent et al.
patent: 4661635 (1987-04-01), Carson
patent: 4675321 (1987-06-01), Baldwin et al.
patent: 4677101 (1987-06-01), Claremon et al.
patent: 4769483 (1988-09-01), Lombardi et al.
patent: 4797411 (1989-01-01), Crugnola et al.
patent: 4808718 (1989-02-01), Hartman et al.
patent: 4839369 (1989-06-01), Youssefyeh et al.
patent: 4916145 (1990-04-01), Tilley et al.
patent: 4925664 (1990-05-01), Jackson et al.
patent: 4925873 (1990-05-01), Friedhoff et al.
patent: 4967003 (1990-10-01), Rentzea et al.
patent: 4988730 (1991-01-01), Korbonits et al.
patent: 5001251 (1991-03-01), MacManus et al.
patent: 5011834 (1991-04-01), Weber et al.
patent: 5021599 (1991-06-01), Beer et al.
patent: 5030576 (1991-07-01), Dull et al.
patent: 5034514 (1991-07-01), Nitecki et al.
patent: 5053337 (1991-10-01), Weinshank et al.
patent: 5064657 (1991-11-01), Jackson et al.
patent: 5073648 (1991-12-01), Hagishita et al.
patent: 5075338 (1991-12-01), Knoll et al.
patent: 5082837 (1992-01-01), Palfreyman
patent: 5334628 (1994-08-01), Maeda et al.
patent: 5403861 (1995-04-01), Goldin et al.
patent: 5504253 (1996-04-01), VanWegenen et al.
patent: 5648541 (1997-07-01), VanWegenen et al.
patent: 5763569 (1998-06-01), Brown et al.
Anderson and Santi, "Phenylalanyl Transfer Ribonucleic Acid Synthetase from Escherichia coli B. Potent Inhibition by Analogues of N-Benzyl-2-phenylethylamine," J. Med. Chem. 19:1270-1275 (1976).
Arjona et al., "Sterochemistry of the reduction of the imino group. IV. Sterochemistry of the reduction of N-(1-phenylethyl)-1-alkyl-1-arylmethanimines," An. Quim. Ser. C 81(1):23-29 (1985).
Barney et al., "A Convenient Synthesis of Hindered Amines and .alpha.-Trifluoromethylamines from Ketones," Tetrahedron Letters 31:5547-5550 (1990).
Batra and Alenfall, "Effects of Diverse Categories of Drugs on Human Colon Tumour Cell Proliferation," Anticancer Research 11:1221-1224 (1991).
Becalski et al., "Catalytic asymmetric hydrogenation of imines. Use of rhodium(I)/phosphine comploexes and characterization of rhodium(I)/imine complexes," Chemical Abstracts 116:558 at Abstract No. 14742U (1992).
Bertz et al., "Asymmetric Induction with Amidocuprates," J. Org. Chem. 51:4953-4959 (1986).
Boyd et al., "Dynamic Sterochemistry of Imines and Derivatives. Part 18. Photosynthesis and Photoracemization of Optically Active Oxaziridines," J. Chem. Soc. Perkin Trans. I 4:849-855 (1985).
Bringmann et al., "The Enantioselective Synthesis of Optically Active, Benzene Nucleus-Substituted 1-Phenylethylamines from the Corresponding Acetophenones," Leibigs Ann.Chem. 5:795-805 (1990).
Bringmann et al., "Enantiomerically Pure N-Boc Protected .beta.-Keto-.gamma.-Amino Acid Esters from Simple Keto Precursors: A Novel, Stereocontrolled Approach to Statine Derivatives with Any Desired Configuration," SYNLET Letters pp. 253-255 (1990).
Brown et al., "A Comparison of the Effects of Divalent and Trivalent Cations on Parathyroid Hormone Release, 3', 5'-Cyclic-Adenosine Monophosphate Accumulation, and the Levels of Inositol Phosphates in Bovine Parathyroid Cells," Endocrinology 127:1064-1071 (1990).
Brown et al, "Cloning and characterization of an extracellular Ca.sup.2+ sensing receptor from bovine parathryoid," Nature 366:575-580 (1993).
Brown, "Extracellular Ca.sup.2+ Sensing, Regulation of Parathyroid Cell Function and Role of Ca.sup.2+ and Other Ions as Extracellular (First) Messengers," Physiological Reviews 71:371-411 (1991).
Brown et al., "High Extracellular Ca.sup.2+ and Mg.sup.2+ Stimulate Accumulation of Inositol Phosphates in Bovine Parathyroid Cells," FEBS Letters 218:113-118 (1987).
Brown et al., "Neomycin Mimics the Effects of High Extracellular Calcium Concentrations on Parathyroid Function in Dispersed Bovine Parathyroid Cells," Endocrinology 128:3047-3054 (1991).
Brown et al., "Polyarginine, Polylysine, and Protamine Mimic the Effects of High Extracellular Calcium Concentrations on Dispersed Bovine Parathyroid Cells," Journal of Bone and Mineral Research 6:1217-1225 (1991).
Capuano et al., "Characterization of the Human Calcium Receptor Gene," Journal of Bone and Mineral Research 9(1):S145 at abstract No. 98 (1994).
Chemical Abstracts Formula Index, vol. 110 p. 537F (1989).
Chemical Abstracts Formula Index, vol. 110 p. 1793F (1989).
Chen et al., "Injection of Bovine Parathyroid Poly(A).sup.+ RNA into Xenopus Oocytes Confers Sensitivity to High Extracellular Calcium," Journal of Bone and Mineral Research 9:293-300 (1994).
Chen and Brown, "The Diltiazem Analog TA-3090 Mimics the Actions of High Extracellular Ca.sup.2+ on Parathyroid Function in Dispersed Bovine Parathyroid Cells," Journal of Bone and Mineral Research 5:581-587 (1990).
Clifton et al., "Arylethanolamines derived from salicylamide with alpha- and beta-adrenoceptor blocking activities. Preparation of labetalol, its enantiomers and related salicylamides," J. Med. Chem. 25:670-679 (1982).
Danks, "Reaction of Hydride Transfer Reducing Agents with (1-Heterodiene) Tricarbonyliron(0) Complexes and the Synthesis of Saturated Amines and Alcohols," Tetrahedron Letters 35:4177-4178 (1994).
Davies and Ichihara, "Asymmetric Synthesis of R-.beta.-Amino Butanoic Acid and S-.beta.-Tyrosine: Homochiral Lithium Amide Equivalents for Michael Additions to .alpha.,.beta.-Unsaturated Esters," Tetrahedron: Asymmetry 2:183-186 (1991).
De Feo et al., "Natriuretic Peptide Receptors Regulate Endothelin Synthesis and Release From Parathyroid Cells," Proc. Natl. Acad. Sci. USA 88:6496-6500 (1991).
Fox et al., "A First Generation Calcimimetic Compound (NPS R-568) That Acts on the Parathyroid Cell Calcium Receptor: A Novel Therapeutic Approach for Hyperparathyroidism," Journal of Bone and Mineral Research 8(1):S181 at abstract No. 260 (1993).
Fox et al., "NPS R-568 Acts on Calcium Receptors to Inhibit Parathyroid Hormone and Stimulate Calcitonin Secretion: A Novel Therapeutic Approach for Hyperparathyroidisum," J. American Society of Nephrology 4:719 at abstract No. 120P (1993).
Fox et al., "NPS R-568 Inhibits Parathyroid Hormone Secretion and Stimulates Calcitonin Secretion in Hyperparathyroid Rats with Chronic Renal Failure," J. American Society of Nephrology 4:719 at abstract No. 69P (1993).
Fox et al., "Parathyroid Gland Calcium Receptor Gene Expression is Unaffected by Chronic Renal Failure or Low Dietary Calcium in Rats," J. Am. Soc. Nephrology 5:879 at abstract No. 90P (1994).
Fox et al., "Physiologically Relevant PTH Levels are Anabolic on Bone in Ovariectomized Rats," Bone 16(Supplement):194S at abstract No. 434 (1995).
Fox et al., "Prevention of Hypocalcemia Prolongs the Plasma Parathyroid Hormone and Calcitonin Responses to the Calcimimetic Compound NPS R-568 in Rats," Journal of Bone and Mineral Research 9(1):

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