Inhibition of matrix metalloproteases by substituted phenalkyl c

Details Inhibition of matrix metalloproteases by substituted phenalkyl c Inhibition of matrix metalloproteases by substituted phenalkyl c

1997-05-15

1998-09-08

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142378, 514533, 514563, 344169, 344171, 560 39, 560 41, 562442, 562444, 562449, 562450, A61K 31195, A61K 31535, C07D29513, C07D295192

Patent

active

058045813

ABSTRACT:
Matrix metalloprotease inhibiting compounds, pharmaceutical compositions thereof and a method of disease treatment using such compounds are presented. The compounds of the invention have the generalized formula: ##STR1## wherein T is a substituent and R.sup.24 is a substituted amide moiety. These compounds are useful for inhibiting matrix metalloproteases and, therefore, combating conditions to which MMP's contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal disease, corneal ulceration, proteinuria, aneurysmal aortic disease, dystrophobic epidermolysis, bullosa, conditions leading to inflammatory responses, osteopenias mediated by MMP activity, tempera mandibular joint disease, demyelating diseases of the nervous system, tumor metastasis or degenerative cartilage loss following traumatic joint injury, and coronary thrombosis from athrosclerotic plaque rupture. The present invention also provides pharmaceutical compositions and methods for treating such conditions.

REFERENCES:
Kluender et al, Chemical Abstracts, vol. 125, No. 142275 (1997).
International Search Report, International Application No. PCT/US 97/07919.
Rasmussen and MCCann, Pharmacol. Ther., 75 69-75 (1997).
Conway, et al., Clin. Exp. Metastasis, 14, 115-124 (1996).
Santos, et al., Clin. Exp. Metastasis, 15, 499-508 (1997).

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