Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Transferases
Patent
1999-01-08
2000-06-06
Carlson, Karen Cochrane
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Transferases
435193, 512 12, A61K 3845, C12N 910
Patent
active
060715138
ABSTRACT:
The invention provides a human glutathione-S-transferase (HGST) and polynucleotides which identify and encode HGST. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HGST.
REFERENCES:
The Merck Index. Eighth Edition Rahway: Merck & Co, Inc., p. 500, 1968.
Thier, R., et al., "Expression of mammalian glutathione S-transferase 5--5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes", Proc Natl Acad Sci USA, 90: 8576-8580 (1993).
Simula, T.P., et al., "Human glutathione S-transferase-expressing Salmonella typhimurium tester strains to study the activation/detoxification of mutagenic compounds: studies with halogenated compounds, aromatic amines and aflatoxin B1", Carcinogenesis, 14: 1371-1376 (1993).
Dirven, H.A., et al., "Involvement of Human Glutathione S-transferase Isoenzymes in the Conjugation of Cyclophosphamide Metabolites with Glutathione", Cancer Res, 54: 6215-6220 (1994).
Yokomizo, A., et al., "Markedly Decreased Expression of Glutathione S-Transferase .pi. Gene in Human Cancer Cell Lines Resistant to Buthionine Sulfoximine, and Inhibitor of Cellular Glutathione Synthesis", J Biol Chem, 270: 19451-19457 (1995).
Kodym, R., et al., (GI 1899207) GenBank Sequence Database (Accession U90313), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. (1899208).
Corley Neil C.
Shah Purvi
Yue Henry
Bugaisky Gabriele E.
Carlson Karen Cochrane
Incyte Pharmaceuticals Inc.
Muenzen Colette C.
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