Heterocyclic ketone and thioester compounds and uses

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C544S059000

Reexamination Certificate

active

06984639

ABSTRACT:
This invention relates to neurotrophic, low molecular weight, small molecule heterocyclic ketone and thioester compounds, compositions containing the same, and the use of such compounds for treating neurological disorders, including physically damaged nerves and neurodegenerative diseases.

REFERENCES:
patent: 3203961 (1965-08-01), Wu
patent: 3458515 (1969-07-01), Archibald
patent: 3459770 (1969-08-01), Freed
patent: 4053599 (1977-10-01), Effland
patent: 4310461 (1982-01-01), Krapcho
patent: 4374829 (1983-02-01), Harris
patent: 4390695 (1983-06-01), Krapcho
patent: 4531964 (1985-07-01), Shimano
patent: 4574079 (1986-03-01), Gavras
patent: 4578474 (1986-03-01), Krapcho
patent: 4593102 (1986-06-01), Shanklin, Jr.
patent: 4766110 (1988-08-01), Ryan
patent: 4808573 (1989-02-01), Gold
patent: 4818749 (1989-04-01), Gold
patent: 4857524 (1989-08-01), Furukawa
patent: 4912128 (1990-03-01), Henning
patent: 4916146 (1990-04-01), Tanaka
patent: 5028604 (1991-07-01), Tarizuka
patent: 5147877 (1992-09-01), Goulet
patent: 5166317 (1992-11-01), Wallace
patent: 5192773 (1993-03-01), Armistead
patent: 5215969 (1993-06-01), Springer
patent: 5232923 (1993-08-01), Fukazawa
patent: 5252579 (1993-10-01), Skotnicki
patent: 5294603 (1994-03-01), Rinehart
patent: 5319098 (1994-06-01), Burbaum
patent: 5321041 (1994-06-01), Adachi
patent: 5330993 (1994-07-01), Armistead
patent: 5359138 (1994-10-01), Takeuchi
patent: 5385918 (1995-01-01), Connell
patent: 5414083 (1995-05-01), Hackl
patent: 5424454 (1995-06-01), Burbaum
patent: 5447915 (1995-09-01), Schreiber
patent: 5516797 (1996-05-01), Armistead
patent: 5543423 (1996-08-01), Zelle
patent: 5717092 (1998-02-01), Armistead
patent: 5786378 (1998-07-01), Hamilton
patent: 5990131 (1999-11-01), Hamilton
patent: 6037370 (2000-03-01), Armistead
patent: 6124328 (2000-09-01), Armistead
patent: 6218424 (2001-04-01), Hamilton
patent: 6274602 (2001-08-01), Steiner et al.
patent: 6486151 (2002-11-01), Hamilton et al.
patent: 3508251 (1986-09-01), None
patent: 3931051 (1990-03-01), None
patent: 4015255 (1991-11-01), None
patent: 12401 (1980-06-01), None
patent: 48159 (1982-03-01), None
patent: 50800 (1982-05-01), None
patent: 73143 (1983-03-01), None
patent: 88350 (1983-09-01), None
patent: 196841 (1986-10-01), None
patent: 260118 (1988-03-01), None
patent: 333174 (1989-09-01), None
patent: 352000 (1990-01-01), None
patent: 378318 (1990-07-01), None
patent: 405994 (1991-01-01), None
patent: 419049 (1991-03-01), None
patent: 468339 (1992-01-01), None
patent: 572365 (1993-12-01), None
patent: 0597291 (1994-05-01), None
patent: 652229 (1995-05-01), None
patent: 2247456 (1992-03-01), None
patent: 4149166 (1992-05-01), None
patent: 05178824 (1993-07-01), None
patent: WO 88/09789 (1988-12-01), None
patent: WO 90/12805 (1990-11-01), None
patent: WO 91/04985 (1991-04-01), None
patent: WO 91/13088 (1991-09-01), None
patent: WO 92/00278 (1992-01-01), None
patent: WO 92/03472 (1992-03-01), None
patent: WO 92/04370 (1992-03-01), None
patent: WO 92/16501 (1992-10-01), None
patent: WO 92/18478 (1992-10-01), None
patent: WO 92/19593 (1992-11-01), None
patent: WO 92/19745 (1992-11-01), None
patent: WO 92/21313 (1992-12-01), None
patent: WO 93/07269 (1993-04-01), None
patent: WO 93/13066 (1993-07-01), None
patent: WO 93/23548 (1993-11-01), None
patent: WO 93/25546 (1993-12-01), None
patent: WO 94/05639 (1994-03-01), None
patent: WO 94/07858 (1994-04-01), None
patent: WO 94/13629 (1994-06-01), None
patent: WO 95/12572 (1995-05-01), None
patent: WO 95/24385 (1995-09-01), None
patent: WO 95/26337 (1995-10-01), None
patent: WO 95/35308 (1995-12-01), None
patent: WO 95/35367 (1995-12-01), None
patent: WO 96/06097 (1996-02-01), None
patent: WO 96/15101 (1996-05-01), None
patent: WO 96/17816 (1996-06-01), None
patent: WO 96/41609 (1996-12-01), None
patent: WO 97/36869 (1997-10-01), None
patent: 9207782 (1993-04-01), None
US 5,654,332, 8/1997, Armistead (withdrawn)
Askin, et al., “Efficient Degradation of FK-506 to a versatile synthetic intermediate,”J. Org. Chem., 1990, vol. 55(20), pp. 55451-55454.
Goulet, et al., “Degradative studies on the tricarbonyl containing macrolide rapamycin,”Tetrahedron Lett., 1990, vol. 31(34), PP. 4845-4848.
Jones, et al., “Chemistry of tricarbonyl hemiketals and application of Evans technology to the total synthesis of the immunosuppressant (−)—FK-506,”J. Am. Chem. Soc., 1990, vol. 112(8), pp. 2998-3017.
Jones, et al., “A formal synthesis of FK-506. Exploration of some alternatives to macrolactamization,”J. Org. Chem., 1990, vol. 55(9), pp. 2786-2797.
Rao, et al., “Studies directed towards the synthesis of immunosuppresive agent FK-506: construction of the tricarbonyl moiety,”Tetrahedron Lett., 1990, vol. 31(10), pp. 1439-1442.
Harding, et al., “A receptor for the immunosuppresive FK506 is a cis-trans peptidyl-prolyl isomerase,”Nature Lett., 1989, vol. 341, pp. 758-760.
Finberg, et al., “Prevention of HIV-1 Infection and Preservation of CD4 Function by the Binding of CPFs to gp120,”Science, 1990, vol. 249, pp. 287-291.
Goodfellow, et al., “p-Nitrophenyl 3-diazopyruvate and diazopyruvamide, a New Family of Photoactivatable Cross-Linking Bioprobes,”Biochemistry, vol. 28(15), pp. 6346-60.
Wasserman, et al., “Synthesis of the tricarbonyl region of FK-506 through an amidophosphorane [Erratum to document cited in CA111(7):57366p],”J. Org. Chem., 1989, vol. 54(22), p. 5406.
Wasserman, et al., “Synthesis of the tricarbonyl region of FK-506 through an amidosphere,”J. Org. Chem., 1989, vol. 54(12), pp. 2785-2786.
Dragovich, et al., “Structured-Based Design of Novel, Urea-Containing FKBP12 Inhibitors,”J. Med. Chem., 1996, vol. 39, pp. 1872-1884.
Gold, et al., “The Immunosuppressant FK506 Increases the Rate of Axonal Regeneration in Rat Sciatic Nerve,”The Journal of Neuroscienc, 1995, vol. 15(11), pp. 7509-7516.
Gold, et al., “The Immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury,”Restorative Neurology and Neuroscience, 1994, vol. 6, pp. 287-296.
Lyons, et al., “Immunosuppressant FK506 promotes neurite outgrowth in culture of PC12 cells and sensory ganglia,”Proc. Natl. Acad. Sci. USA, 1994, vol. 91, pp. 3191-3195.
Gold, et al., “Multiple signals underlie the anatomy-induced up regulation of c-JUN in adult sensory neurons,”Neuroscience Letters 176, 1994, pp. 123-127.
Gold, et al., “Regulation of the transcription factor c-JUN by nerve growth factor in adult sensory neurons,”Neuroscience Letters 154, 1993, pp. 129-133.
Askin, et al., “Chemistry of FK-506: benzilic acid rearrangement of the tricarbonyl system,” Tetrahedron Lett., 1989, vol. 30(6), pp. 671-674.
Coleman, et al., “Degradation and manipulations of the immunosupressant FK506: preparation of potantial synthetic intermediates,”Heterocycles, 1989, vol. 28(1), pp. 157-161.
Faelth, et al., “Interactions between C=S groups in 1, 2 and 1, 3-bis (thiocarbonyl) Compounds: A Study by Spectroscopy, X-Ray Crystallography, and CNDO/S Calculations,”THEOCHEM, 1989, vol. 55, pp. 239-259.
Doulmedais, et al., “Sterochemistry of Electrochemical Reduction of Optically Active ∝-ketoamides. II. Electroreduction of benzoylformamides derived from S-(−)-proline,”Bull. Soc. Chim. Fr., 1989, vol. (2), pp. 185-201. (French).
Soai, et al., “Asymmetric Allylation of ∝-keto amides Derived from (S)-proline esters,”Pept. Chem., 1986, vol. 24, pp. 327-330.
Munegumi, et al., “Asymmetric Catalytic Hydrogenations of N-pyruvoyl-(s)-proline esters,”Bull. Chem. Soc. Jpn., 1987, vol. 60(1), pp. 243-253.
Soai, et al., “Diasteroselective asymmetric allylation of chiral ∝-keto amides with allyltrimethylsilane. Preparation of protected homoallylic alcohols,”J. Chem. Soc., 1984, vol. 15, pp. 1016-1017.
Soai, et al., “Sodium borohydride

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Heterocyclic ketone and thioester compounds and uses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Heterocyclic ketone and thioester compounds and uses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Heterocyclic ketone and thioester compounds and uses will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3528892

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.