Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1995-05-18
1998-01-06
Chambers, Jasemine C.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424450, 514 44, 435 691, 4351723, 435 72, 4353201, 935 62, 935 55, 935 54, 935 71, A61K 4800, C12N 1563, C12N 1509, C12N 500
Patent
active
057051518
ABSTRACT:
The present invention provides a nucleic acid-based therapeutic composition to treat an animal with disease by controlling the activity of effector cells, including T cells, macrophages, monocytes and/or natural killer cells, in the animal. The present invention also relates to methods of gene therapy involving different modes of administration of a therapeutic composition to treat animals with different types of diseases. Also included in the present invention are recombinant molecules for use in a therapeutic composition and recombinant cells useful as a tumor vaccine. Therapeutic compositions of the present invention include superantigen-encoding nucleic acid molecules, either in the presence or absence of a cytokine-encoding nucleic acid molecule, depending upon the disease being treated.
REFERENCES:
Blackman et al., Life Sci., 57(19):1717-1735, 1995.
Donnelly et al., Ann. N.Y. Acad. Sci., 772:40-46, 1995.
Liu, Ann. N.Y. Acad. Sci., 772(DNA Vaccines):15-21, 1995.
Miethke et al., Int. Arch. Allergy Immunol., 106:3-7, 1995.
Miethke et al., Immunobiol., 189:270-284, 1993.
Liu et al., 1997, Nature Biotechnology, 15:167-173.
Dow Steve W.
Elmslie Robyn E.
Chambers Jasemine C.
Hauda Karen M.
National Jewish Center for Immunology & Respiratory Medicine
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