Gamma-pyrone-3-acetic acid as an inhibitor or interleukin-1 .bet

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

549420, A61K 3135

Patent

active

054119855

ABSTRACT:
Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1.beta. converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula I are also useful in treating the complications of infection (e.g., gram negative shock) and tumors in which IL 1 functions as an autocrine growth factor or as a mediator of cachexia. ##STR1##

REFERENCES:
patent: 4603144 (1986-07-01), Campbell et al.
Engel, et al., Helv. Chim. Acta 32 pp. 1752-1758 (1949).
Mycofaxon (46) pp. 141-154 (1993) A Synoptic Key to Xylaria Species from Continental United States and Canada Based on Cultural and Anamorphic Features.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Gamma-pyrone-3-acetic acid as an inhibitor or interleukin-1 .bet does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Gamma-pyrone-3-acetic acid as an inhibitor or interleukin-1 .bet, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gamma-pyrone-3-acetic acid as an inhibitor or interleukin-1 .bet will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1137404

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.