Estrogen nucleus derivatives for use in the inhibition of sex st

Details Estrogen nucleus derivatives for use in the inhibition of sex st Estrogen nucleus derivatives for use in the inhibition of sex st

1993-02-12

1997-05-20

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

552514, 540 15, A61K 31565, A61K 3156, C07J 3100

Patent

active

056312490

ABSTRACT:
Novel compounds for the inhibition of sex steroid activity for the treatment of both androgen-related and estrogen-related diseases include for example 15- and 16-halo substituted compounds such as: ##STR1## The compounds are characterized by an estrogenic nucleus substituted with a substituent of the formula --R.sup.1 [B--R.sup.2 --].sub.x L--G

REFERENCES:
patent: 2875199 (1959-02-01), Cella et al.
patent: 3493606 (1970-02-01), Richardson
patent: 3562260 (1971-02-01), Ruggieri et al.
patent: 3637856 (1972-01-01), Richardson
patent: 3995060 (1976-11-01), Neri et al.
patent: 4094994 (1978-06-01), Schonenberger
patent: 4096253 (1978-06-01), Watchter et al.
patent: 4139638 (1979-02-01), Neri et al.
patent: 4161540 (1979-07-01), Neri et al.
patent: 4198435 (1980-04-01), Richardson
patent: 4307111 (1981-12-01), Crawley
patent: 4386080 (1983-05-01), Crossley et al.
patent: 4472382 (1984-09-01), Labrie
patent: 4536516 (1985-08-01), Harper et al.
patent: 4623660 (1986-11-01), Richardson
patent: 4636505 (1987-01-01), Tucker et al.
patent: 4659516 (1987-04-01), Bowler et al.
patent: 4659695 (1987-04-01), Labrie
patent: 4728640 (1988-03-01), Labrie et al.
patent: 4732912 (1988-03-01), Pilgrim et al.
patent: 4743589 (1988-05-01), Labrie et al.
patent: 4745102 (1989-05-01), Labrie et al.
patent: 4751240 (1988-06-01), Bowler et al.
patent: 4760053 (1988-07-01), Labrie
patent: 4760061 (1988-07-01), Edwards et al.
patent: 4775660 (1988-10-01), Labrie et al.
patent: 4833135 (1989-05-01), Edwards et al.
patent: 5023234 (1991-06-01), Labrie
patent: 5064813 (1991-11-01), Labrie
patent: 5204337 (1993-04-01), Labrie et al.
patent: 5364847 (1994-11-01), Labrie
patent: 5372996 (1994-12-01), Labrie
patent: 5393785 (1995-02-01), Labrie
patent: 5550107 (1996-08-01), Labrie
Wakeling, et al., "Steroidal Pure Antioestrogens", J. Endocrinol. (1987), 112, R7-R10.
H. Mouridsen, et al., Cancer Treatment Review 5, 131-141, (1978).
Klijn, et al., J. J. Steroid BioChem. 420, No. 66, 1381 (1984).
Wakeling, et al. J. Steroid BioChem., 30:141-147, 1988.
Bucourt, et al., J. Biol. Chem., 253:8221, 1978.
Thomas, et al. J. Biol. Chem., 258:11500, 1983.
B. Tobias et al., J. Biol. Chem., 257, 2783-2786, 1982.
R. J. Auchus, et al., Biochemistry, 25, 7295-7300, 1986.
Levesque et al. J. Med. Chem., 34, (1991), pp. 1624-1630.
Heiman, et al., J. Med. Chem., 23, (1980), pp. 994-1002.
Fevig, et al., Steroids, 51 (1988), pp. 471-497.
R. T. Blickenstaff, et al., "Synthesis of Some Analogs of Estradiol", Steroids, vol. 46, No. 4, 5, Nov. (1985), pp. 889-902.
Landvatter, et al., "Non-Steroidal Estrogens: Synthesis and Estrogen Receptor Binding Affinity of Derivatives of . . .", J. Med. Chem. 1982.
Weatherill, et al., "Interactino of Antiestrogen ICI 164, 384 with Oestrogen Receptor", J. Steroid Biochem., vol. 30, No. 1-6, pp. 263-266 (1988).
Doberauer, et al., "Advanced Male Breast Cancer Treatment with the LH-RH Analog Buser . . . ", Cancer, 62:pp.474-478, (1988).
Sinard, et al. Mec. Endocrinol 2:775-784 (1988).
U.S. Application: 07/699,710, Filed Feb. 8, 1984.
U.S. Application: 07/146,597, Filed Jan. 21, 1988.
Furr, et al., J. Endocr. 113, R7-R9, 1987.
Jordan, et al. "Regulation of Prolactin Synthesis in Vitro By Estrogenic and Antiestrogenic Derivatives of Estradiol and Estrone", Endocrinology, 124(4):1717-1725 (1989).
C.C. Chin, et al., J. Biol. Chem., 250, 7682-7686, 1975.
Y.M. Bhatnagar, et al. J. Biol. Chem. 253, 811-815 1978.
C.C. Chin, et al., J. Biol. Chem., 255, 3660-2664, 1980.
J.L. Thomas, et al., J. Biol. Chem., 258, 1587-1590, 1983.
Von Angerer, et al., J. Med. Chem., 27:1439-1447, 1984.

Affiliated with

Also associated with

Rating

Estrogen nucleus derivatives for use in the inhibition of sex st does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Estrogen nucleus derivatives for use in the inhibition of sex st, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Estrogen nucleus derivatives for use in the inhibition of sex st will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1724030