Erythromycin aldobionates

Details Erythromycin aldobionates Erythromycin aldobionates

1976-06-01

1979-01-30

Raymond, Richard

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, 536 17, 536115, C07C 1708

Patent

active

041373979

ABSTRACT:
This invention relates to a novel process for the preparation of Erythromycin aldobionates and novel Erythromycin maltobionates, Erythromycin Cellobionate and Erythromycin mellibionate. The said process comprises converting an alkali metal salt of aldobionic acid into free aldobionic acid, neutralizing the obtained aldobionic acid with Erythromycin base and finally recovering the Erythromycin aldobionate.

REFERENCES:
patent: 3873614 (1975-03-01), Lamberti et al.
Avrutskaya et al., "Electro synthesis . . . Nickel Electrodes", Sov. Electrochem (USA), vol. 9, No. 6, Jun. 1973.
Chem. Abst. Chem. Substance Index, vol. 84, p. 1946(cs), 1976, "Enythromycin".
Kolesinska, "Lactobionic Acid and its Salts", Chem. Abst., vol. 70, 1969, parg. 6523q.
Parker et al., "Solution Additive . . . Study", Chem. Abst., vol. 67, 1967, parg. 102720k.
Garrett, "Basic Model . . . Concentrations", Chem. Abst. vol. 84, 1976, parg. 54650q.
Websters Third International Dict. 1963, Springfield Mass. (Merriam Co.) C. Owens, p. 51.
Hale, "Simple Procedures", Ion Exchanges in Org. & Biochemistry, 1957, Interscience Publishers, NY p. 131.
Rodd, Chem. of Org. (Carbon) Cpds., vol. III, part A, 1954, Elsevier Publ. Co., NY p. 88.

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