Diarylacetylenes, the preparation and use thereof

Details Diarylacetylenes, the preparation and use thereof Diarylacetylenes, the preparation and use thereof

1990-08-01

1992-02-11

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514772, 514708, 514710, 514713, 514825, 514859, 514861, 514863, A61K 31335

Patent

active

050876376

ABSTRACT:
Diarylacetylenes of the formula I ##STR1## where R.sup.1 is hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sup.2 and R.sup.3 are each hydrogen or, when R.sup.1 is hydrogen, together form a --C(CH.sub.3).sub.2 --B--C(CH.sub.3).sub.2 -- group (where B is --CH.sub.2 Ch.sub.2 -- or --CH(CH.sub.3)--) or --OC(Ch.sub.3) (Z)CH.sub.2 CH.sub.2 -- group (where Z is C.sub.1 -C.sub.2 -alkyl) or R.sup.2 is C.sub.1 -C.sub.3 -alkoxy and R.sup.3 is C.sub.1 -C.sub.10 -alkyl or, when R.sup.2 is hydrogen, R.sup.1 and R.sup.3 are each alkyl as defined above, R.sup.4 is C.sub.1 -C.sub.6 -alkyl and n is 0, 1 or 2, are prepared as described and used as active compounds in drugs and cosmetics.

REFERENCES:
patent: 4326055 (1982-04-01), Loeliger
patent: 4806558 (1989-02-01), Wuest et al.
patent: 4810804 (1989-03-01), Chandraratna
patent: 4895868 (1990-01-01), Chandraratna
patent: 4940707 (1990-07-01), Klaus et al.
patent: 4994489 (1991-02-01), Wuest et al.
Journal of the American Chemical Society, vol. 93, No. 12, 16 Jun. 1971, Gaston, PA, pp. 2974-2981; John J. Eisch et al., "Polar and Stereochemical Effects in the Addition of Triphenylaluminum to Para--substituted Diphenylacetylenes".

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