Cyclosporine metabolites

Details Cyclosporine metabolites Cyclosporine metabolites

1990-06-06

1993-04-13

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530317, 530321, A61K 3700, A61K 3702, C07K 500, C07K 700

Patent

active

052023109

ABSTRACT:
A cyclosporine metabolite having a molecular weight determined by mass spectrometry of about 1205 and having the following properties: (a) being immunologically distinct from cyclosporine metabolites OL-1, OL-17 and OL-8; (b) being more polar than OL-1 or OL-17 and less polar than OL-8 when eluated from a gradient high performance liquid chromatography; (c) being extractable from bile of test animals which have been administered cyclosporine A; and (d) being substantially free of other cyclosporine metabolites and cyclosporine A, and a physiologically acceptable salt or stereoisomer thereof.

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