CNS depressant .gamma.-(secondary amino)-ortho-nitro-butyropheno

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...

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260268PH, 2602936, 26029366, 26029367, 26029368, 26029379, 2602938, 2603436, 260592, 424250, C07D21128, A61K 31445

Patent

active

040753468

ABSTRACT:
Novel compounds of the formula: ##STR1## wherein R is a hydrogen or fluorine atom, W is an oxygen atom or an ethylenedioxy or ethylenedithio group and Z is a certain secondary amino group, which are useful as central nervous system depressants, can be prepared by the reaction of a compound of the formula: ##STR2## wherein X is a halogen atom and R and W are each as defined above with a secondary amine of the formula: H--Z wherein Z is as defined above, in case of W being ethylenedioxy or ethylenedithio, optionally followed by hydrolysis and can be reduced to give a compound of the formula: ##STR3## wherein R and Z are each as defined above, which are useful as antipsychotic and/or analgesic agents.

REFERENCES:
patent: 3408356 (1968-10-01), Horovitz
patent: 3799932 (1974-03-01), Yamamoto et al.

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