Chlormethiazole in the treatment of neurodegeneration

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61K 31425

Patent

active

053995724

ABSTRACT:
A thiazole of the following formula is disclosed ##STR1## for the treatment of neurodegeneration involving loss of neuronal structure.

REFERENCES:
M. Ende, et al., Urinary Metabolites of Clomethiazole, Arzneim-Forsch/Drug. Res. 29 (II) Nr. 11, pp. 1655-1658 (1979).
R. Pal, et al., Thiomethylation and Thiohydroxylation-A New Pathway of Metabolism of Heterocyclic Compounds, Xenobiotica, vol. 12, No. 12, pp. 813-820 (1982).
C. P. Offen, et al., 4,5-Dimethylthiazole-N-Oxide-S-Oxide; A Metabolite of Chlormethiazole In Man, Xenobiotica, vol. 15, No. 6, pp. 503-511 (1985).
A. R. Green, et al., A Simple Intravenous Infusion Method In Rodents For Determining the Potency of Anticonvulsants Acting Through GABAergic Mechanisms, J. Pharm. Pharmacol. 41; 879-800 (1989).
Goodman and Gilman's The Pharmacological Basis of Therapeutics Seventh Edition, pp. 13, 357, 454 and 455 (1985).
D. V. Parke, Recent Advances In Pharmacology, 4th Ed., p. 68, (1968) reprinted In Taylor et al. Introductory Medicinal Chemistry, p. 182.
Alfred Burger, A Guide To The Chemical Basis of Drug Design, p. 137 (1983).
Paul L. Ornstein, et al., Synthesis and Pharmacology Of A Series of 3- and 4-(Phosphonoalkyl)Pyridine-And-Piperidine-2-Carboxylic Acids. Potent N-Methyl-D-Aspartate Receptor Antagonists, J. Med. Chem. 32, 827 (1989).
C. W. Cotman et al., Excitatory Amino Acids In The Brain--Focus On NMDA Receptors, TINS, vol. 10, No. 7, pp. 263-265 (1987).
William F. Maragos, et al., Glutamate dysfunction in Alzheimer's disease: an hypothesis, TINS 10, 65-68 (1987).
N. T. Gurusinghe, et al., Chlormethiazole In The Management Of Post-Cranitomy Seizures, Acta. Psychiatr. Scand. Suppl. 329, vol. 73, pp. 189-193 (1986).
S. A. Ather, et al., A Comparison Of Chlormethiazole And Thioridazine In Agitated Confusional States Of The Elderly, Acta. Psychiatr. Scand. Suppl. 329, vol. 73, pp. 81-91 (1986).
T. V. Stanley, Oral Chlormethiazole In Childhood Epilepsy, Archives Of Disease In Childhood, vol. 57, pp. 242-243 (1982).
Louis Low et al., Prolonged Intravenous Use of Chlormethiazole (Heminevrin), British Medical Journal, p. 484 (1980).
F. Nouailhat et al., abstract of Treatment of Status Epilepticus In The Adult, Rev. Electroencephalogr. Neurophysiol Clin. 14, 237 (1985).
C. Carlsson et al., Influence of Chlormethiazole On Cerebral Blood Flow and Oxygen Consumption In The Rat, And Its Effect On The Recovery of Cortical Energy Metabolism After Pronounced, Incomplete Ischaemia, Acta. Anaesth. Scand. 23, 259-266 (1979).
M. G. Mead et al., Confusion And Hypnotics In Demented Patients, Journal Of The Royal College Of General Practitioners 32, 763-765 (1982).
Chemical Abstract 66: 45369f (1967).
Chemical Abstract 79: 40671g (1973).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Chlormethiazole in the treatment of neurodegeneration does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chlormethiazole in the treatment of neurodegeneration, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chlormethiazole in the treatment of neurodegeneration will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1149129

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.