Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1990-06-01
1993-06-01
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
514355, 514356, 5142312, A61K 4900, A61K 3144, A61K 3154
Patent
active
052157385
ABSTRACT:
A method for radiosensitizing hypoxic tumor cells in a warm-blooded animal is provided. The method involves administration of a nicotinamide compound having the structural formula ##STR1## wherein X is O or S, and Z is H, OR, SR or NHR where R is as defined herein. Exemplary compounds for use in conjunction with the disclosed method include: 5-hydroxynicotinamide; 5-hydroxynicotinamide, sodium salt; 5-(2,3-dihydroxypropoxy)nicotinamide; 5-aminonicotinamide; 5-(2-methoxyethylamino)nicotinamide; and 5-acetamidonicotinamide.
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Brown J. Martin
Grange Edward W.
Lee William W.
Martinez Abelardo P.
Criares Theodore J.
Goldberg Jerome D.
Reed Dianne E.
SRI - International
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