Azetidin-2-one derivatives as serine protease inhibitors

Details Azetidin-2-one derivatives as serine protease inhibitors Azetidin-2-one derivatives as serine protease inhibitors

1992-10-06

1993-10-05

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540362, 540357, 540359, 540360, C07D20508, C07D20509, C07D24700, A61K 31395

Patent

active

052506770

ABSTRACT:
The present invention relates to new 3-guanidinoalkyl-2-azetidinones of the formula ##STR1## wherein: U and W can be the same or different and are selected from the group consisting of hydrogen and an amino protecting group;

REFERENCES:
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patent: 4637999 (1987-01-01), Doherty et al.
patent: 4680391 (1987-07-01), Firestone et al.
patent: 4699904 (1987-10-01), Doherty et al.
patent: 4717722 (1988-01-01), Doherty et al.
patent: 4845088 (1989-07-01), Doherty et al.
Doherty, et al., Cephalosporin Antibiotics can be Modified to Inhibit Human Leukecyte Elastase, Nature, 322, p. 192 (1986).
Gianfranco, C., et al. Stereocontrolled Total Synthesis of Chiral Building Block (3S,4R)-3-[(R)-1-Hydroethyl]-4-Acetyloxy-Azetidin-2-One; A Useful Synthon for the Synthesis of (+)-Thienamycin, Carbapenems and Penems. Tetrahedron Letters, 26, No. 7, pp. 937-940, (1985).

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