Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1992-07-29
1993-09-14
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514305, 514618, 514826, 514859, 514863, 514885, 514886, 540583, 546133, 564162, A61K 3155, A61K 3144, A61K 3165, C07D22300
Patent
active
052448991
ABSTRACT:
The compounds of this invention are azabicyclic and azatricyclic amides represented by the formula: ##STR1## wherein: R.sub.1 and R.sub.2 are the same or different members of the group consisting of halo, phenyl, substituted phenyl and a ##STR2## group wherein n, m and p are independently an integer of from 1 to 8 provided that n+m+p is equal to or less than 10; X is thio, sulfinyl or sulfonyl; Alk is straight or branched chain lower alkylene; R.sub.3 is selected from the group consisting of a azabicycloalkylamino, azatricycloalkylamino or dicycloalkylamino. The compounds are useful as anti-inflammatory and anti-allergy agents.
REFERENCES:
patent: 3392194 (1968-07-01), Waring
patent: 3624143 (1971-11-01), Shen et al.
patent: 3652646 (1972-03-01), Leigh et al.
patent: 4029812 (1977-06-01), Wagner et al.
patent: 4076841 (1978-02-01), Wagner et al.
patent: 4078084 (1978-03-01), Wagner et al.
patent: 4534874 (1985-08-01), Steinberg et al.
Samuelsson, "Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflamation", Science, vol. 220, May 6, 1983, pp. 568-575.
Bach, "Inhibitors of Leukotriene Synthesis and Action", The Leukotrienes, Chemistry and Biology, Academic Press, pp. 163-194 (1984).
Lee, et al., "Human Biology and Immunoreactivity of Leukotrienes", Advances in Inflammation Research, vol. 6, pp. 219-225, Raven Press (1984).
Editorial, "Leukotrienes and other Lipoxygenase Products in the Pathegonesis and Therapy of Psoriasis and Dermatoses", Arch. Dermatol., vol. 119, pp. 541-547, (Jul. 1983).
Lewis, et al., "A Review of Recent Contributions on Biologically Active Products of Arachidonate Conversion", Int. J. Immunopharmac., vol. 4, No. 2, pp. 85-90, (1982).
Bach, "Prospects for the Inhibition of Leukotriene Synthesis", Biochemical Pharmacology, vol. 33, No. 4, pp. 515-521 (1984).
Becker, "Chemotactic factors of Inflammation", pp. 223-225, (Elsevier Science Publishers B. V. Amsterdam, 1983).
Sharon, et al., "Enhanced Synthesis of Leukotriene B.sub.4 by Colonic Mucosa in Inflammatory Bowel Disease", Gastroenterology, vol. 86, pp. 453-460, (Mar. 1984).
Musch, et al., "Stimulation of Colonic Secretion by Lipoxygenase Metabolites of Arachidonic Acid", Science, vol. 217, p. 1255 (Sep. 24, 1982).
Harvey, et al., "The Preferential Inhibition of 5-Lipoxygenase Product Formation by Benoxaprofen", J. Pharm. Pharmacol., vol. 35, pp. 44-45, (1983).
Chem. Abst. 90:151802x vol. 90 (1979).
Khim. Tekhnol. 20(4), pp. 568-574 (1977).
Pestic. Biochem. Physiol, 12(1), 23-30 (1979).
Deason James R.
Mueller Richard A.
Partis Richard A.
Criares T. J.
G. D. Searle and Co.
Hastreiter Roberta L.
Matukaitis Paul D.
Waddell Frederick E.
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