Anti-carcinoma therapeutic agent of glycosaminoglycans and cytos

Details Anti-carcinoma therapeutic agent of glycosaminoglycans and cytos Anti-carcinoma therapeutic agent of glycosaminoglycans and cytos

1985-08-28

1988-04-19

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424 941, 424 946, A61K 31725

Patent

active

047389559

ABSTRACT:
A combination consisting of a mixture comprising high-molecular and low-molecular glycosaminoglycan polysulfates as well as a cytostatic agent is effective to obtain improved results in selectively killing quiescent tumor cells. This effect may be reinforced by adding a lipolytic and/or proteolytic enzyme.

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patent: 4389392 (1983-06-01), Adachi
patent: 4565806 (1986-01-01), Setala
Ishida et al., JBC, 258(a), 1983, pp. 5933-5937.
Lipinski et al., J. Immunol., 1982, p. 2301.
Wiels et al., Cancer Res., 1984, p. 129.
Nirdelmon et al., Science, 220, 1983, p. 509.
Journal of Medicinal Chemistry, 1974, vol. 17, No. 12, p. 1335.
Hoppe-Seyler's Z. Physiol. Chem., 357, S., 499-508, Apr. 1976.

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