3-Substituted-5-alkyl-1,6-naphthyridin-2(1H)-ones, cardiotonic u

Details 3-Substituted-5-alkyl-1,6-naphthyridin-2(1H)-ones, cardiotonic u 3-Substituted-5-alkyl-1,6-naphthyridin-2(1H)-ones, cardiotonic u

1984-10-11

1985-12-17

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546122, 546123, A61K 31435, C07D47104

Patent

active

045593477

ABSTRACT:
1-R"-3-Q-4-R'-5-R-1,6-naphthyridin-2(1H)-ones (I) or salts thereof, where R is lower-alkyl, R' is hydrogen or methyl, R" is hydrogen or lower-alkyl, and Q is hydrogen, hydroxy, amino, cyano, carbamyl, carboxy or aminocarbamyl, are useful as cardiotonic agents (I, Q is hydrogen, hydroxy, amino, cyano or carbamyl) and/or intermediates therefor (I, Q is carboxy, aminocarbamyl, hydrogen, amino, cyano or carbamyl). Also shown are 3-Q'-4-R'-5-(RCO)-6-[2-di-lower-alkylamino)ethenyl]-2(1H)-pyridinones (II) or salts thereof, where R and R' are as above and Q' is hydrogen or cyano, which are useful as cardiotonics (II, Q' is hydrogen) and/or intermediates (II, Q' is cyano or hydrogen). Processes for preparing the compounds of formulas I and II are shown.

REFERENCES:
Robert Morrison and Robert Boyd, "Organic Chemistry," 2nd Ed., Allyn and Bacon, Inc., Boston, (1966).
Alfred Burger, J. of Chemical Education, 33, 362(8), 1956.
Chemical Abstracts 72, 12,615d, (1970).
Ogata et al., [Chem. Pharm. Bull. 20, 2264, (1972)].
Hawes et al., [J. Med. Chem. 16, 849, (1974)].
Hawes et al., [J. Heterocycl. Chem. 11, 151, (1974)].
Moller et al., [Ann. 612, 153, (1957)].

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