Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-01-08
1998-04-28
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540359, A61K 31395, C07D20508
Patent
active
057444676
ABSTRACT:
Sulfur-substituted azetidinone hypocholesterolemic agents of the formula ##STR1## or a pharmaceutically acceptable salt thereof are disclosed, as well as pharmaceutical compositions containing them, and a method of lowering serum cholesterol by administering said compounds, alone or in combination with a cholesterol biosynthesis inhibitor.
REFERENCES:
patent: 4680391 (1987-07-01), Firestone et al.
patent: 4983597 (1991-01-01), Yang et al.
patent: 5120729 (1992-06-01), Chabala et al.
patent: 5412092 (1995-05-01), Rey
Ram et al, Indian J. Chem., Sect B 29B, 12 (1990), pp. 1134-1137.
Witzum, Circulation, 80, 5 (1989), pp. 1101-1114.
Illingworth, Drugs, 36(Supp. 3) (1988), pp. 63-71.
Allain, et al, Clin. Chem., 20, (1974), pp. 470-475.
Schnitzer-Polokoff, et al, Comp.Biochem. Physiol., 99A (1991), pp. 665-670.
Horie, et al, Atherosclerosis, 88 (1991), pp. 183-192.
Baxter, et al, J. Biological Chem., 267, 17 (1992), pp. 11705-11708.
Current Drugs: Anti-Atherosclerotic Agents --Summary Factfile, May, 1992.
Harwood, et al, Journal of Lipid Research, 34 (1993), pp. 377-395.
Atherosclerosis, 115 (1995), pp. 45-63.
Bose et al, Org. Magn. Reson., 12, 1 (1979), pp. 34-38.
Burnett Duane A.
Dugar Sundeep
McKittrick Brian A.
Ivy C. Warren
M. Mach D. Margaret
Magatti Anita W.
Schering Corporation
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