α-2/δ gene

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

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C530S412000, C536S023500

Reexamination Certificate

active

09787657

ABSTRACT:
The present invention relates to three novel genes and polypeptides derived therefrom encoding “α2δ-C” and/or “α2δ-D” proteins which exist as a subunit in many calcium channels. The invention also describes methods for using the novel gene and polypeptides in the detection of genetic deletions of the gene, subcellular localization of the polypeptide, binding assays in connection with chemical databases, gene therapy.

REFERENCES:
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patent: 0012711 (2000-03-01), None
Myers, R.M. GenBank Accession No. G36524, Dec. 31, 1997.
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Database EMBL 'Online!, AC AC005343, Muzny et al., 1998.
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Gee et al., “The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the α2δ Subunit of a Calcium Channel”,The Journal of Biological Chemistry, vol. 271, No. 1, 1996, pp. 5768-5776.
Brown and Gee, “Cloning and Deletion Mutagenesis of the α2δ Calcium Channel Subunit from Porcine Cerebral Cortex”,The Journal of Biological Chemistry, vol. 273, No. 39, 1998, pp. 24458-25465.
Klugbauer et al., “Molecular Diversity of the Calcium Channel α2δ Subunit”,The Journal of Neuroscience, vol. 19, No. 2, 1999, pp. 654-691.
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