Vinblastine synthesis

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

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435190, 435192, C12P 1718, C12N 904, C12N 908

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active

050343203

ABSTRACT:
The reaction of 3',4'-anhydrovinblastine with a Catharanthus roseus-derived protein fraction to form vinblastine is improved by conducting the reaction in the presence of a reducing agent such as the enzyme cofactor NADH. A cationic species such as manganous ion may also be added to the reaction. Vinblastine yields are enhanced.

REFERENCES:
Endo et al., "Biotransformation of Anhydrouinblastine to Vinblastine by a Cell-Free Extract of Catharanthus roseus Cell Suspension Cultures", Phytochemistry, vol. 26, 3233-3234, 1987.
Stich et al., "Investigation of Hydrogen Peroxide Formation in Plants", Phytochemistry, vol. 23, 2719-2722, 1984.
Stuart et al., "Studies on the Synthesis of Bisindole Alkaloids, Enzyme Catalysed formation of Heutosine", Heterocycles, vol. 9, 1015-1022, 1978.
Baxter et al., "Biosynthesis of the Antitumor Catharanthus Alkaloids, Conversion of an Hydrovinblastine to Vinblastine", J.C.S. Chem. Comm., vol. 6, pp. 257-259, 1979.
Goldberg et al., "The Final Stages of Lignin Biosynthesis", J. Exp. Bot., vol. 36 (164), 503-510, 1985.
Stuart et al., "Studies on the Biosynthesis of Bisindole Alkaloids, The Final Stages in Biosynthesis of Vinblastine, Heurosine and Catharine", Heterocycles, vol. 9 (10), 1391-1395, 1978.
McLauchlan et al., "Conversion of Anhydrovinblastine to Vinblastine by Cell-Free Homogenates of Catharanthus roseus cell Suspension Cultures", Tett., vol. 39, 3777-80, 1983.
Kutney et al., "Alkaloid Production in Catharanthus roseus Cell Cultures, Biotransformation of 3',4'-Anhydrovinblastine to Other Bisindole Alkaloids", vol. 65, 1271-78, 1982, Helvetica Chimica Acta.

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