Vaccine against varicella-zoster virus

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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435 91, 435 68, 435 70, 4351723, 4353171, 435320, 935 12, C07H 1512, C12P 2102, C12N 1500, C12N 100

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048125598

ABSTRACT:
A gene of varicella-zoster virus (VZV) which encodes immunogenic outer surface viral proteins has been identified by DNA sequence analysis. This gene can hybrid select messenger RNA which encodes and expresses a protein which reacts with human convalescent zoster sera and with polyclonal monospecific antisera which neutralize viral infectivity. These proteins are useful for the preparation of a vaccine for VZV.

REFERENCES:
Ellis et al. (1985) J. Virology, vol. 53, pp. 81-88.
Davidson et al. (1985), J. Gen. Virol., vol. 66, pp. 207-220.
Davidson (1983) EMBO J., vol. 2, pp. 2203-2209.

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