Tetrapeptide regulating blood glucose level in diabetes...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Reexamination Certificate



The invention refers to the field of medicine and can be applied as a substance capable of regulating glucose level while treating and preventing diabetes mellitus. There is proposed a biologically active new tetrapeptide lysyl-glutamyl-aspartyl-tryp-tophane of general formula Lys-Glu-Asp-Trp-NH2capable of regulating the glucose level, and pharmacological substance containing an effective amount of tetrapeptide lysyl-glutamyl-aspartyl-tryptophane of the general formula Lys-Glu-Asp-Trp-NH2. There is proposed the method of prevention and/or treatment of the diabetes mellitus, which consists in administering to a patient of the pharmacological substance, containing as an active peptide agent an effective amount of Lys-Glu-Asp-Trp-NH2tetrapeptide in doses of 0.1-30 μg/kg of the body weight at least once a day for a period necessary for attaining a therapeutic effect.

patent: 6180103 (2001-01-01), Cohen et al.
patent: 7101854 (2006-09-01), Khavinson
patent: 2004/0054130 (2004-03-01), Ng et al.
patent: 2078769 (1997-05-01), None
patent: WO 01/72770 (2001-10-01), None
Schatz et al. Why Can't We Prevent Type 1 Diabetes. Diabetes Care, Dec. 2003. vol. 26, No. 12, pp. 3326-3328.
National Diabetes Fact Sheet. http://www.cdc.gov/diabetes/pubs/general.htm accessed online Apr. 7, 2008; pp. 1-4.
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Balabolkin, M.I.,Diabetology, Mockba 2000 pp. 572-583.
Register of Pharmaceutical Substances, Acarbose pp. 58-59, Glipizide pp. 236-237, Metformin pp. 517-518, Siofor p. 759.


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