Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
C435S091100, C536S024300, C436S063000
A genetic locus and corresponding family of proteins associated with regulation of immune development, function, and cell survival are provided. The locus comprising the TIM family is genetically associated with immune dysfunction, including atopy, autoimmunity, inflammatory bowel disease, dysplasia, and susceptibility to blood-bourne infectious diseases. Polymorphisms in the human TIM-1 gene and exposure to Hepatitis A Virus (HAV) are shown to be associated with protection from the development of atopy.
patent: 5721351 (1998-02-01), Levinson
patent: 6204371 (2001-03-01), Levinson
patent: 6288218 (2001-09-01), Levinson
patent: 2003/0124114 (2003-07-01), McIntire
Kroese et al. Genetics in Medicine, vol. 6 (2004), p. 475-480.
Lucentini The Scientist, 2004, vol. 18, p. 20.
Noguchi et al. Genes and Immunity (2003) 4:170-173.
Umetsu et al. Ann NY Acad Sci, 2004, 1029:88-93.
Graves et al. J Allerg Clin Immunol, 2005, vol. 118, pp. 650-656.
Mummidi et al. , J Biol. Chem, Jun. 23, 2000, 275(25): 18946-61.
GeneCard for Tim-1, Hepatitis A virus cellular receptor 1, available online at www.genecard.org, pp. 1-11.
Ionnidis, Plost Med., 2005, 2(8), e124.
Hegel, Arth. Thromb. Vasc. Biol. 2002, vol. 22, pp. 1058-1061.
Hattersley et al, Lancet, 2005, vol. 366, pp. 1315-1323.
McIntire et al. (Nature, 2003, vol. 425, p. 576).
Monney, et al., “Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease,” (2002)Nature, 415:536-541.
NCBI Annotation Project, “Direct Submission,” (2002)National Center for Biotechnology Information, NIH, Bethseda, MD 20894, Genbank accession No. XM—011327.
Ota, et al., “Complete sequencing and characterization of 21,243 full-length human cDNAs,” (2004)Nat. Genet., 36(1):40-45, Genbank accession No. BAB55044.
McIntire Jennifer Jones
Umetsu Dale T.
Bozicevic Field & Francis LLP
Dana-Farber Cancer Institute
Sherwood Pamela J.
The Board of Trustees of the Leland Stanford Junior University
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